Results 71 to 80 of about 922,430 (265)

Regional geomagnetic core field and secular variation model over the Iberian Peninsula from 2014 to 2020 based on the R-SCHA technique

Earth, Planets and Space, 2023
The Earth’s magnetic field originated in the fluid core, the so-called core field, is the dominant contribution to the geomagnetic field. Since ancient times, the core geomagnetic field has been used primarily for geographical orientation and navigation ...
Marina Puente-Borque, F. Javier Pavón-Carrasco, Alberto Núñez, José Manuel Tordesillas, Saioa A. Campuzano   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Magnetic Field Alignment with Dense Cores in the Transition between Cloud and Core Scales

The Astrophysical Journal
In a magnetically dominated model of star formation, we expect to see alignments between the magnetic field orientation of star-forming dense cores and the cloud-scale magnetic field. A. Pandhi et al.
Sean Yin, Ayush Pandhi, Rachel Friesen, Simon Coudé, Laura Fissel, Sarah Sadavoy, James Di Francesco, Doug Johnstone, Frédérick Poidevin, Mehrnoosh Tahani   +9 more
doaj   +1 more source

Study on Vibration Characteristics of Power Transformer Core and Oil Tank and the Correlation with Near Field Noise

Zhongguo dianli, 2020
The noise of the transformer is mainly generated by the vibration of the oil tank, which is mainly generated by the vibration of the iron core, while the vibration of the iron core is mainly generated by the electromagnetic force.
Chao FAN, Jingkai NIE, Weimin XIAO, Guangzhou WANG, Shengchang JI, Fuyao YANG, Yang LIU, Pengyu DU   +7 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

MR imaging quality and feasibility of a novel interleaved iTBS/fMRI setup

Brain Stimulation, 2023
Kai-Yen Chang, Yuki Mizutani-Tiebel, Martin Tik, Mattia Campana, Lucia Bulubas, Christian Windischberger, Frank Padberg, Daniel Keeser   +7 more
doaj   +1 more source

Magnetic Field Control Using an Electromagnetic Actuation System with Combined Air‐Core and Metal‐Core Coils

Advanced Intelligent Systems
Magnetic fields are widely utilized for remote control of magnetic objects, with various actuation systems developed for manipulating miniature robots in research and biomedical applications.
Nader Latifi Gharamaleki, Dong‐in Kim, Gyudong Lee, Jin‐Young Kim, Hongsoo Choi   +4 more
doaj   +1 more source