Results 61 to 70 of about 10,532,208 (291)
On the force field optimisation of $$\beta$$-lactam cores using the force field Toolkit
Journal of Computer-Aided Molecular Design, 2022 AbstractWhen employing molecular dynamics (MD) simulations for computer-aided drug design, the quality of the used force fields is highly important. Here we present reparametrisations of the force fields for the core molecules from 9 different $$\beta$$ β -lactam classes, for which we utilized the force field Toolkit ...
Qiyang Wu +6 more
openaire +3 more sources
Element 5 Assessment Plan with Final Report Template Core General Education Assessment, 2021-2022
, 2022 The Assessment Plan with Final Report Template for Element 5 - Social Science as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core +1 more source
Quantum Omni-Synthesis I: Core Field-Theoretical Framework
Quantum ReportsThe Quantum Omni-Synthesis (QOS) framework is inspired by the cosmological constant problem, the dark sector, and the tension that arises when gravity is treated as purely geometrical while quantum fields remain defined on a fixed background.
Stefalo Acha
doaj +1 more source
Geomagnetic Dipole Changes and Upwelling/Downwelling at the Top of the Earth's Core
Frontiers in Earth Science, 2018 The convective state of the top of Earth's outer core is still under debate. Conflicting evidence from seismology and geomagnetism provides arguments for and against a thick stably stratified layer below the core-mantle boundary.
Ludovic Huguet +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A Long-lived Lunar Magnetic Field Powered by Convection in the Core and a Basal Magma Ocean
The Planetary Science Journal, 2023 An internally generated magnetic field once existed on the Moon. This field reached high intensities (∼10–100 μ T, perhaps intermittently) from ∼4.3 to 3.6 Gyr ago and then weakened to ≲5 μ T before dissipating by ∼1.9–0.8 Gyr ago.
Saira S. Hamid +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Earth, Planets and Space, 2014 I quantitatively test a method of toroidal field imaging at the core-mantle boundary (CMB) using a synthetic magnetic field and core surface flow data from a 3-D self-consistent numerical dynamo model with a thin electrically conducting layer overlying ...
Futoshi Takahashi
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On the equivalence of the hybrid particle–field and Gaussian core models
The Journal of Chemical Physics, 2023 Hybrid particle–field molecular dynamics is a molecular simulation strategy, wherein particles couple to a density field instead of through ordinary pair potentials. Traditionally considered a mean-field theory, a momentum and energy-conserving hybrid particle–field formalism has recently been introduced, which was demonstrated to approach the Gaussian
Morten Ledum +3 more
openaire +3 more sources