Results 71 to 80 of about 977,559 (266)
Mercury's Northern Rise Core-Field Magnetic Anomaly. [PDF]
Geophys Res Lett, 2021 Plattner AM, Johnson CL.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Analysis and Optimization of Rubber Core Structure of Rotary BOP
Shiyou jixie, 2021 Rotary blowout preventer(BOP)is a key equipment for underbalanced drilling, and its sealing performance is an important factor to ensure safety during operation under pressure. The existing domestic-made rotary BOPs have problems such as weak rubber core
Liu Weimin
doaj
Inverse problem for the Earth's core evolution model
Russian Journal of Earth Sciences, 2020 The size and the age of the inner core impose constraints in modeling of the Earth's core evolution. The origin of the solid core corresponds to the change in convection regime in the core and, correspondingly, to the change in the magnetic field ...
Reshetnyak M Yu
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The influence of regularization on the geomagnetic core field modeling
地球与行星物理论评Earth's magnetic field is generated through the dynamo action in the liquid outer core. Using observational data from geomagnetic satellites and observatories, we can construct geomagnetic models that describe spatial and temporal variations of the core ...
Juyuan Xu, Yufeng Lin, Keke Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Direct URCA-processes in neutron star quark core with strong magnetic field.
EPJ Web of Conferences, 2017 Neutrino emissivity in direct URCA processes in superdense strongly magnetized quark medium is calculated. In calculations, we use the covariant method of density matrixes for charge fermions in uniform constant magnetic field.
Belyaev Vasily, Gvozdev Alexander
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source