Results 41 to 50 of about 9,371,907 (195)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Effective Field Theory and the No-Core Shell Model
EPJ Web of Conferences, 2010 In finite model space suitable for many-body calculations via the no-core shell model (NCSM), I illustrate the direct application of the effective field theory (EFT) principles to solving the many-body Schrödinger equation. Two different avenues for fixing
Stetcua I.
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Quantum Omni-Synthesis I: Core Field-Theoretical Framework
Quantum ReportsThe Quantum Omni-Synthesis (QOS) framework is inspired by the cosmological constant problem, the dark sector, and the tension that arises when gravity is treated as purely geometrical while quantum fields remain defined on a fixed background.
Stefalo Acha
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Geomagnetic Dipole Changes and Upwelling/Downwelling at the Top of the Earth's Core
Frontiers in Earth Science, 2018 The convective state of the top of Earth's outer core is still under debate. Conflicting evidence from seismology and geomagnetism provides arguments for and against a thick stably stratified layer below the core-mantle boundary.
Ludovic Huguet +3 more
doaj +1 more source
A Long-lived Lunar Magnetic Field Powered by Convection in the Core and a Basal Magma Ocean
The Planetary Science Journal, 2023 An internally generated magnetic field once existed on the Moon. This field reached high intensities (∼10–100 μ T, perhaps intermittently) from ∼4.3 to 3.6 Gyr ago and then weakened to ≲5 μ T before dissipating by ∼1.9–0.8 Gyr ago.
Saira S. Hamid +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Earth, Planets and Space, 2014 I quantitatively test a method of toroidal field imaging at the core-mantle boundary (CMB) using a synthetic magnetic field and core surface flow data from a 3-D self-consistent numerical dynamo model with a thin electrically conducting layer overlying ...
Futoshi Takahashi
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source