Results 111 to 120 of about 4,042,841 (387)

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

clonevdjseq: A workflow and bioinformatics management system for sequencing, archiving, and analysis of VDJ sequences from clonal libraries

BMC Bioinformatics
Background Advances in next-generation sequencing technologies have facilitated extensive analysis of B cell and T cell receptor (BCR/TCR, respectively) sequences from monoclonal hybridoma libraries, single B cells, and single T cells, generating vast ...
Keith Mitchell, Samuel Hunter, Lutz Froenicke, Karl Murray, Matthew Settles, James S. Trimmer   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder

Translational Psychiatry
While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we mapped the methylome of the caudate nucleus and
Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Stefano Marenco, Philip Shaw   +8 more
doaj   +1 more source

Whole-genome comparative analysis of virulence genes unveils similarities and differences between endophytes and other symbiotic bacteria

Frontiers in Microbiology, 2015
Plant pathogens and endophytes co-exist and often interact with the host plant and within its microbial community. The outcome of these interactions may lead to healthy plants through beneficial interactions, or to disease through the inducible ...
Sebastian eLòpez-Fernàndez, Paolo eSonego, Marco eMoretto, Michael ePancher, Kristof eEngelen, Ilaria ePertot, Andrea eCampisano   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Comparative chloroplast genomic analyses revealed extensive genomic arrangement in some core and non-core caryophyllales

Bangladesh Journal of Plant Taxonomy, 2019
The order Caryophyllales exhibit diverse diversity in morphology to molecules, which leads to taxonomic complexities in circumscribing especially to its families. The comparative analysis of the available chloroplast genome to detect pattern of genomic arrangement and variation is lacking; hence, the alignment pattern and genomic rearrangement across ...
openaire   +1 more source

The cyanobacterial genome core and the origin of photosynthesis [PDF]

Proceedings of the National Academy of Sciences, 2006
Comparative analysis of 15 complete cyanobacterial genome sequences, including “near minimal” genomes of five strains of Prochlorococcus spp., revealed 1,054 protein families [core cyanobacterial clusters of orthologous groups of proteins (core CyOGs)] encoded in at least 14 of them.
Armen Y, Mulkidjanian, Eugene V, Koonin, Kira S, Makarova, Sergey L, Mekhedov, Alexander, Sorokin, Yuri I, Wolf, Alexis, Dufresne, Frédéric, Partensky, Henry, Burd, Denis, Kaznadzey, Robert, Haselkorn, Michael Y, Galperin   +11 more
openaire   +2 more sources

Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors

Scientific Reports
Breast cancer is a prevalent and significant cause of mortality in women, and manifests as six molecular subtypes. Its further histologic classification into non-invasive ductal or lobular carcinoma (DCIS) and invasive carcinoma (ILC or IDC) underscores ...
Vasiliki Pantazi, Vanda Miklós, Paul Smith, Orsolya Oláh-Németh, Gabriella Pankotai-Bodó, Divya Teja Dondapati, Ferhan Ayaydin, Vincenzo D’Angiolella, Tibor Pankotai   +8 more
doaj   +1 more source