Results 141 to 150 of about 4,042,841 (387)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Whole genome profiling to generate a core physical map of the gene rich part of the sugarcane genome : [W778] [PDF]

, 2014
The sugarcane genome poses challenges that have not been addressed in any prior genome sequencing project. The main difficulties reside in its high polyploidy (2n ~ 12x ~ 120), and its high level of heterozygosity which makes an assembly of the whole ...
Charron, Carine, D'Hont, Angélique, Droc, Gaëtan, Garsmeur, Olivier, Harrison, Bandie, Martin, Guillaume, Van der Vossen, Edwin, Van-Oeveren, Jan, Woltinge, Dennis   +8 more
core  

Development and evaluation of a core genome multilocus typing scheme for whole-genome sequence-based typing of Acinetobacter baumannii

PLoS ONE, 2017
We have employed whole genome sequencing to define and evaluate a core genome multilocus sequence typing (cgMLST) scheme for Acinetobacter baumannii. To define a core genome we downloaded a total of 1,573 putative A.
P. Higgins, K. Prior, D. Harmsen, H. Seifert   +3 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A comparative analysis of library prep approaches for sequencing low input translatome samples

BMC Genomics, 2018
Background Cell type-specific ribosome-pulldown has become an increasingly popular method for analysis of gene expression. It allows for expression analysis from intact tissues and monitoring of protein synthesis in vivo.
Yang Song, Beatrice Milon, Sandra Ott, Xuechu Zhao, Lisa Sadzewicz, Amol Shetty, Erich T. Boger, Luke J. Tallon, Robert J. Morell, Anup Mahurkar, Ronna Hertzano   +10 more
doaj   +1 more source

Core Genome Multilocus Sequence Typing Scheme for Stable, Comparative Analyses of Campylobacter jejuni and C. coli Human Disease Isolates

Journal of Clinical Microbiology, 2017
Human campylobacteriosis, caused by Campylobacter jejuni and C. coli, remains a leading cause of bacterial gastroenteritis in many countries, but the epidemiology of campylobacteriosis outbreaks remains poorly defined, largely due to limitations in the ...
A. Cody, J. Bray, K. Jolley, N. McCarthy, M. Maiden   +4 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Comparative Genomics Analysis of a New Exiguobacterium Strain from Salar de Huasco Reveals a Repertoire of Stress-Related Genes and Arsenic Resistance [PDF]

, 2017
Indexación: Web of Science; Scopus.The Atacama Desert hosts diverse ecosystems including salt flats and shallow Andean lakes. Several heavy metals are found in the Atacama Desert, and microorganisms growing in this environment show varying levels of ...
Aguayo, D., Aguilar, P., Castro-Nallar, E., Castro-Severyn, J., Dorador, C., Fortt, J., Molina, F., Pardo-Esté, C., Quatrini, R., Remonsellez, F., Saavedra, C.P., Salinas, C., Valenzuela, S.L.   +12 more
core   +3 more sources

The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes [PDF]

, 2023
Sébastien Santini, Quentin Schenkelaars, Cyril Jourda, Marc Duchesne, Hassiba Belahbib, Caroline Rocher, Marjorie Selva, Ana Riesgo, Michel Vervoort, Sally P. Leys, Laurent Kodjabachian, André Le Bivic, Carole Borchiellini, Jean‐Michel Claverie, Emmanuelle Renard   +14 more
openalex   +1 more source

Defining and Evaluating a Core Genome Multilocus Sequence Typing Scheme for Genome-Wide Typing of Clostridium difficile

Journal of Clinical Microbiology, 2018
Clostridium difficile, recently renamed Clostridioides difficile, is the most common cause of antibiotic-associated nosocomial gastrointestinal infections worldwide.
S. Bletz, S. Janežič, D. Harmsen, M. Rupnik, A. Mellmann   +4 more
semanticscholar   +1 more source