Results 181 to 190 of about 4,042,841 (387)

A Large Open Pangenome and a Small Core Genome for Giant Pandoraviruses

Frontiers in Microbiology, 2018
Giant viruses of amoebae are distinct from classical viruses by the giant size of their virions and genomes. Pandoraviruses are the record holders in size of genomes and number of predicted genes. Three strains, P. salinus, P. dulcis, and P.
S. Aherfi, J. Andreani, E. Baptiste, Amina Oumessoum, F. Dornas, A. C. Andrade, E. Chabrière, J. Abrahão, A. Levasseur, D. Raoult, B. La Scola, P. Colson   +11 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Molecular characterisation of Salmonella serovars Anatum and Ealing associated with two historical outbreaks, linked to contaminated powdered infant formula

Frontiers in Microbiology, 2016
Powdered infant formula (PIF) is not intended to be produced as a sterile product unless explicitly stated and on occasion may become contaminated during production with pathogens such as Salmonella enterica.
Lynda Gunn, Sarah Finn, Daniel Hurley, Li Bai, Li Bai, Ellen Wall, Carol Iversen, John E Threlfall, Séamus Fanning   +8 more
doaj   +1 more source

Secondary metabolism of the forest pathogen Dothistroma septosporum : a thesis presented in the partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Genetics at Massey University, Manawatu, New Zealand [PDF]

, 2016
Dothistroma septosporum is a fungus causing the disease Dothistroma needle blight (DNB) on more than 80 pine species in 76 countries, and causes serious economic losses. A secondary metabolite (SM) dothistromin, produced by D. septosporum, is a virulence
Ozturk, Ibrahim Kutay
core  

Molecular epidemiology of Staphylococcus aureus bacteremia in a single large Minnesota medical center in 2015 as assessed using MLST, core genome MLST and spa typing

PLoS ONE, 2017
Staphylococcus aureus is a leading cause of bacteremia in hospitalized patients. Whether or not S. aureus bacteremia (SAB) is associated with clonality, implicating potential nosocomial transmission, has not, however, been investigated.
Kyung-Hwa Park, K. Greenwood-Quaintance, J. Uhl, S. Cunningham, N. Chia, P. Jeraldo, Priya Sampathkumar, Heidi Nelson, Robin Patel   +8 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Comprehensive Genomic Analysis of Bacillus thuringiensis Serovars: Core Genome Stability and Pan-Genome Expansion

Bangladesh Journal of Microbiology
Bacillus thuringiensis (Bt) is a bacterium widely known for its pesticidal properties, with numerous serovars exhibiting diverse ecological adaptations and pathogenic characteristics. In this study, we performed a comprehensive genomic analysis of 82 Bacillus thuringiensis serovars retrieved from GenBank, with the aim of investigating their core and ...
Md Saifur Rasul, null Mohammad Mohi Uddin, Sheikh Julfikar Hossain, Md Murshed Hasan Sarkar, null Md Abdullah Al Obaid   +4 more
openaire   +1 more source

Comparative Genomics and Identification of an Enterotoxin-Bearing Pathogenicity Island, SEPI-1/SECI-1, in Staphylococcus epidermidis Pathogenic Strains

Toxins, 2018
Staphylococcus epidermidis is a leading cause of nosocomial infections, majorly resistant to beta-lactam antibiotics, and may transfer several mobile genetic elements among the members of its own species, as well as to Staphylococcus aureus; however, a ...
Xavier Argemi, Chimène Nanoukon, Dissou Affolabi, Daniel Keller, Yves Hansmann, Philippe Riegel, Lamine Baba-Moussa, Gilles Prévost   +7 more
doaj   +1 more source

The nucleotide composition of microbial genomes indicates differential patterns of selection on core and accessory genomes [PDF]

, 2017
Jon Bohlin, Vegard Eldholm, John H.‐O. Pettersson, Ola Brynildsrud, Lars Snipen   +4 more
openalex   +1 more source

Defining a Core Genome Multilocus Sequence Typing Scheme for the Global Epidemiology of Vibrio parahaemolyticus

Journal of Clinical Microbiology, 2017
Vibrio parahaemolyticus is an important human foodborne pathogen whose transmission is associated with the consumption of contaminated seafood, with a growing number of infections reported over recent years worldwide.
N. González-Escalona, K. Jolley, E. Reed, J. Martínez-Urtaza   +3 more
semanticscholar   +1 more source