Advanced Healthcare Materials, EarlyView.Imiquimod‐loaded nanoparticles (PFSUV‐IMQ) are found to decrease liver metastasis and liver tumor burden when administered intravenously. Flow cytometry, RNA‐seq and various experiments show that the anti‐tumor response is immune‐mediated by activating dendritic cells resulting in increased CD8 T cell infiltration and activity.
Vanessa Chan +13 more
wiley +1 more source
Genome-wide profiling of the core clock protein BMAL1 targets reveals strict relationship with metabolism [PDF]
, 2011 Fumiyuki Hatanaka +10 more
openalex +1 more source
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source
The core genome evolution of Lactobacillus crispatus as a driving force for niche competition in the human vaginal tract. [PDF]
Microb Biotechnol, 2023 Tarracchini C +10 more
europepmc +1 more source
CoreGenes3.5: a webserver for the determination of core genes from sets of viral and small bacterial genomes [PDF]
, 2013 Dann Turner +3 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee +9 more
wiley +1 more source
Reconstruction of the last bacterial common ancestor from 183 pangenomes reveals a versatile ancient core genome. [PDF]
Genome Biol, 2023 Hyun JC, Palsson BO.
europepmc +1 more source
Plastome Sequences of Lygodium japonicum and Marsilea crenata Reveal the Genome Organization Transformation from Basal Ferns to Core Leptosporangiates [PDF]
, 2013 Lei Gao +5 more
openalex +1 more source
Software Grand Exposure: SGX Cache Attacks Are Practical
, 2017 Side-channel information leakage is a known limitation of SGX. Researchers have demonstrated that secret-dependent information can be extracted from enclave execution through page-fault access patterns.
Brasser, Ferdinand +5 more
core
Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases
Advanced Materials, EarlyView.This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu +16 more
wiley +1 more source