Results 291 to 300 of about 3,873,112 (365)

RIBAP: a comprehensive bacterial core genome annotation pipeline for pangenome calculation beyond the species level. [PDF]

Genome Biol
Lamkiewicz K, Barf LM, Sachse K, Hölzer M.   +3 more
europepmc   +1 more source

Cre/lox-Mediated CRISPRi Library Reveals Core Genome of a Type I Methanotroph Methylotuvimicrobium buryatense 5GB1C. [PDF]

Appl Environ Microbiol, 2023
Cheng M, Pei D, He L, Fei Q, Yan X.
europepmc   +1 more source

Percent average amino acid identities (AAI) calculated from the core genome data set using EDGAR and MUMi scores of genomic distance between the 12 E. amylovora strains and closely related Erwinia spp.

, 2013
A. Mann Rachel, H M Smits Theo, Andreas Bühlmann, Jochen Blom, Alexander Goesmann, E. Frey Jürg, Plummer Kim M., Verhaegen Steven, Luck Joanne, Duffy Brion, Rodoni Brendan   +10 more
openalex   +1 more source

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis [PDF]

, 2016
Marcin J. Skwark, Nicholas J. Croucher, Santeri Puranen, Claire Chewapreecha, Maiju Pesonen, Ying Xu, Paul Turner, Simon R. Harris, Julian Parkhill, Stephen D. Bentley, Erik Aurell, Jukka Corander   +11 more
openalex   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

The genetic relationship between human and pet isolates: a core genome multilocus sequence analysis of multidrug-resistant bacteria. [PDF]

Antimicrob Resist Infect Control
Genath A, Hackmann C, Denkel L, Weber A, Maechler F, Kola A, Schwarz S, Gastmeier P, Leistner R.   +8 more
europepmc   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

NanoCore: core-genome-based bacterial genomic surveillance and outbreak detection in healthcare facilities from Nanopore and Illumina data. [PDF]

mSystems
Fuchs SA, Hülse L, Tamayo T, Kolbe-Busch S, Pfeffer K, Dilthey AT.   +5 more
europepmc   +1 more source

Exploration of Streptococcus core genome to reveal druggable targets and novel therapeutics against S. pneumoniae. [PDF]

PLoS One, 2022
Chowdhury ZM, Bhattacharjee A, Ahammad I, Hossain MU, Jaber AA, Rahman A, Dev PC, Salimullah M, Keya CA.   +8 more
europepmc   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source