Results 331 to 340 of about 3,873,112 (365)

Development of the Pneumococcal Genome Library, a core genome multilocus sequence typing scheme, and a taxonomic life identification number barcoding system to investigate and define pneumococcal population structure

, 2023
Jansen van Rensburg MJ, Berger DJ, Fohrmann A, Bray JE, Jolley KA, Maiden MC, Brueggemann AB.   +6 more
europepmc   +1 more source

Size of the core genome and dispensable genome and number of strain unique CDS in 21 Mannheimia haemolytica genomes.

, 2016
Liam Cassidy, R. Cook Shaun, Zaheer Rahat, Laing Chad, Philipp Vick, Yong Xu, Rasmussen Jay, Potter Andrew, Hendrick Steve, Williams Trevor, McAllister Tim A.   +10 more
openalex   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

Core-genome scaffold comparison reveals the prevalence that inversion events are associated with pairs of inverted repeats

, 2016
Dan Wang, Shuai Cheng Li, Fei Guo, Lusheng Wang   +3 more
openalex   +2 more sources

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source

Heterogeneity among estimates of the core genome and pan-genome in different pneumococcal populations

, 2017
Andries J. van Tonder, James E. Bray, Keith A. Jolley, Sigríður J. Quirk, Gunnsteinn Haraldsson, Martin Maiden, Stephen D. Bentley, Ásgeir Haraldsson, Helga Erlendsdóttir, Karl G. Kristinsson, Angela B. Brueggemann   +10 more
openalex   +1 more source

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

Advanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang, Linyu Han, Yanfei Huo, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang   +6 more
wiley   +1 more source