Results 351 to 360 of about 3,873,112 (365)

Choroid Plexus Fibroblast–ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury

Advanced Science, EarlyView.
This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong   +10 more
wiley   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

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Analysis of the core genome and pangenome of Clostridium butyricum.

Genome, 2020
Clostridium butyricum is an anaerobic bacterium that inhabits broad niches. Clostridium butyricum is known for its production of butyrate, 1,3-propanediol, and hydrogen. This study aimed to present a comparative pan-genome analysis of 24 strains isolated
W. Zou, Guangbin Ye, Kaizheng Zhang, Haiquan Yang, Jian-gang Yang   +4 more
semanticscholar   +4 more sources

Inferring Core Genome Phylogenies for Bacteria.

Methods in molecular biology, 2021
Due to the increasing availability of public bacterial genome data and cost efficiency of novel bacterial strain sequencing, phylogenetic analyses based on more than a single or few marker genes have become feasible. In this method protocol, we describe the complete bioinformatic workflow from raw genomic data to final phylogenetic analyses based on ...
A. Keller, M. Ankenbrand
semanticscholar   +4 more sources

Comparative bacterial genomics: defining the minimal core genome [PDF]

Antonie van Leeuwenhoek, 2012
A comparative genomics analysis revealed 702 genes present in the bacterial Gram-negative core gene set (92 species analyzed) and 959 genes in the Gram-positive core gene set (93 species analyzed). Mycoplasma genitalium, which has the smallest known genome (517 genes) of a non-symbiont, was used in a three-way reciprocal analysis with the Gram-negative
Jack T. Trevors, C. H. Huang, Tom Hsiang
openaire   +2 more sources

The Core and Pan-Genome of the Vibrionaceae

2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, 2009
Species of the family Vibrionaceae are ubiquitous in marine environments and the family contains numerous important pathogens of humans and marine species. In order to find the core, accessory and pan-proteome of this family, we deduced the complete set of orthologs for eleven strains from this family.
Hong Cai, Jianying Gu, Timothy Lilburn
openaire   +2 more sources

Managing core resources for genomics and proteomics

Pharmacogenomics, 2003
Recent years have seen an explosive growth in biological data, which is often not published in a conventional sense but rather deposited in a database. This trend and the need for computational analyses of the data make databases essential tools for biological research.
Rolf Apweiler, Maria Jesus Martin, Manuela Pruess, Claire O'Donovan   +3 more
openaire   +3 more sources

Genomic Sequencing (Core Article)

2006
Beginning with the landmark work of Watson and Crick and continuing with the technological breakthroughs of the 1970s, 1980s, and the 1990s, molecular genetics and genomics has revolutionized all aspects of biology. Today, scientists are able to decipher the precise order of every nucleotide of an organism's complete genome, using a conceptually simple
Todd Charles Wood, Jeffrey P. Tomkins
openaire   +2 more sources

Core and Accessory Genomes of the Diazotroph Azospirillum

2015
International ...
Victor Gonzáles, Stéphanie Borland, Claire Prigent-Combaret, Igor B. Zhulin, Benoît Drogue, Patrick Mavingui, Kirill Borziak, Florence Wisniewski-Dyé, Luis Lozano   +8 more
openaire   +4 more sources