Results 351 to 360 of about 4,042,841 (387)

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Table 1_Molecular epidemiology of Brucella abortus in Shandong, China: high-resolution insights from combined MLVA-16 and core genome SNP analysis.xlsx

Chanjuan Huangfu (22481278), Xiujun Ma (22481281), Junjie Fan (2040463), Kuo Han (1721350), Ti Liu (14049918), Zengqiang Kou (6746876), Yan Li (23143)   +6 more
openalex   +1 more source

Investigating environmental transmission to resolve a Bacillus cereus group outbreak in a neonatal intensive care unit using core genome multilocus sequence typing. [PDF]

Antimicrob Resist Infect Control
Tönnies H, Heep A, Herrmann J, Lange M, Mellmann A, Hamprecht A.   +5 more
europepmc   +1 more source

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Inferring Core Genome Phylogenies for Bacteria.

Methods in molecular biology, 2021
Due to the increasing availability of public bacterial genome data and cost efficiency of novel bacterial strain sequencing, phylogenetic analyses based on more than a single or few marker genes have become feasible. In this method protocol, we describe the complete bioinformatic workflow from raw genomic data to final phylogenetic analyses based on ...
A. Keller, M. Ankenbrand
semanticscholar   +3 more sources

Core resources for genome analysis

2021
The Wellcome Sanger Institute will sequence and assemble tens of thousands of genomes across the next decade through large-scale biodiversity sequencing projects such as Darwin Tree of Life. The projects span the entire tree of eukaryotic life, and the genomes will enable new and unprecedented science.
Muffato, Matthieu, Blaxter, Mark
openaire   +1 more source

Comparative bacterial genomics: defining the minimal core genome

Antonie van Leeuwenhoek, 2012
A comparative genomics analysis revealed 702 genes present in the bacterial Gram-negative core gene set (92 species analyzed) and 959 genes in the Gram-positive core gene set (93 species analyzed). Mycoplasma genitalium, which has the smallest known genome (517 genes) of a non-symbiont, was used in a three-way reciprocal analysis with the Gram-negative
C H, Huang, T, Hsiang, J T, Trevors
openaire   +2 more sources

Genome Evolution in Malaria Parasites: I. Core Genome Components

2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, 2009
Malaria is one of the most common infectious diseases that affect millions of people globally. It is caused by protozoan parasites in the genus Plasmodium. Existing antimalarials have lost efficacy thanks to the emergence of resistant parasite populations and the incidence of the disease is on the rise.
Hong Cai, Yufeng Wang, Jianying Gu
openaire   +1 more source

Managing core resources for genomics and proteomics

Pharmacogenomics, 2003
Recent years have seen an explosive growth in biological data, which is often not published in a conventional sense but rather deposited in a database. This trend and the need for computational analyses of the data make databases essential tools for biological research.
Rolf, Apweiler, Maria Jesus, Martin, Claire, O'Donovan, Manuela, Pruess   +3 more
openaire   +2 more sources

Analysis of the core genome and pangenome of Clostridium butyricum.

Genome, 2020
Clostridium butyricum is an anaerobic bacterium that inhabits broad niches. Clostridium butyricum is known for its production of butyrate, 1,3-propanediol, and hydrogen. This study aimed to present a comparative pan-genome analysis of 24 strains isolated
W. Zou, Guangbin Ye, Kaizheng Zhang, Haiquan Yang, Jian-gang Yang   +4 more
semanticscholar   +1 more source

Insect genome content phylogeny and functional annotation of core insect genomes

Molecular Phylogenetics and Evolution, 2016
Twenty-one fully sequenced and well annotated insect genomes were examined for genome content in a phylogenetic context. Gene presence/absence matrices and phylogenetic trees were constructed using several phylogenetic criteria. The role of e-value on phylogenetic analysis and genome content characterization is examined using scaled e-value cutoffs and
Jeffrey A, Rosenfeld, Jonathan, Foox, Rob, DeSalle   +2 more
openaire   +2 more sources