Results 31 to 40 of about 181,408 (258)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The m-weak core inverse relative to a Hermitian weight

Demonstratio Mathematica
In this paper, we introduce the concept of E-relative m-weak core inverse of a square matrix as a common extension of the E-weighted core-EP inverse and the m-weak core inverse.
Ferreyra David E., Levis Fabián E., Moas Paola, Mosić Dijana, Orquera Valentina   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inverse design of core-shell particles with discrete material classes using neural networks

Scientific Reports, 2022
The design of scatterers on demand is a challenging task that requires the investigation and development of novel and flexible approaches. In this paper, we propose a machine learning-assisted optimization framework to design multi-layered core-shell ...
Lina Kuhn, Taavi Repän, Carsten Rockstuhl   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Characterizations and representations of weak core inverses and $m$-weak group inverses

Turkish Journal of Mathematics, 2023
In a ring with an involution, we first present some necessary and sufficient conditions for the existence of the $m$-weak group inverse and expression. As an application, we prove that a regular element $a$ is $(m+1)$-weak group invertible if and only if $a^2a^{-}$ is $m$-weak group invertible, where $a^{-}$ is an inner inverse of $a$.
Li, Wende, Chen, Jianlong, Zhou, Yukun
openaire   +1 more source

Research Status and Suggestions of Nuclear Reactor Online Core Monitoring System

Yuanzineng kexue jishu
The online core monitoring system (CMS) is a crucial system for ensuring the safe operation of nuclear power plants. Its primary function is to real-time monitor the key parameter changes within the reactor core, in order to timely detect potential ...
LI Jinggang, LI Wenhuai, ZHANG Xiangju, WANG Junling, WANG Ting, LU Haoliang, PENG Sitao
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The $\mathfrak{m}$-CCE Inverse in Minkowski Space and Its Applications

Axioms
In this paper, we introduce a new generalized inverse called m-CCE inverse which presents a generalization of the CCE inverse in Minkowski space by using the m-core-EP decomposition and the Minkowski inverse.
Xin Tan, Xiaoji Liu
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source