Results 121 to 130 of about 4,674,131 (308)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Research on Deterioration Mechanism and High-Precision Modelling of the Core Loss for Amorphous Alloys after Wire-Cut Electric Discharge Machining. [PDF]

Materials (Basel), 2023
Yang X, Qiu S, Wang Y, Zhao P, Gao Y, Wang H, Zhang C.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Electron energy loss spectroscopy database synthesis and automation of core-loss edge recognition by deep-learning neural networks. [PDF]

Sci Rep, 2022
Kong L, Ji Z, Xin HL.
europepmc   +1 more source

Element 6 Chairs and Course List Core General Education Assessment, 2018-2019

, 2019
The Chairs and Course List for Element 6 - Natural Science as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Development of hollow-core photonic bandgap fibres free of surface modes

, 2009
Conventional optical fibres can only guide light in a high refractive index core by total internal reflection. By using total internal reflections it is not possible to guide light in an air core.
Amezcua-Correa, Rodrigo
core   +1 more source

Fe-Based Amorphous Magnetic Powder Cores with Low Core Loss Fabricated by Novel Gas-Water Combined Atomization Powders. [PDF]

Materials (Basel), 2022
Liu J, Dong Y, Zhu Z, Zhao H, Pang J, Wang P, Zhang J.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Preparation and Characterization of MnFe₂O₄/Fe Soft Magnetic Composites by Surface Oxidation

Metals
MnFe2O4/Fe soft magnetic composites (SMCs) were designed by the surface oxidation method, and the MnFe2O4 layer was utilized as the insulation coating.
Shigeng Li, Rutie Liu, Xiang Xiong
doaj   +1 more source