Results 161 to 170 of about 2,316,046 (304)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Multiphysics Investigation on Thermal Characteristics of Internal Bio-Inspired V-Ribbed Cooling Channels for Outer Rotor PMSM. [PDF]

Biomimetics (Basel)
Xiong X, Li X, You S, Zhu B, Ding P, Gao H, Hou Z.   +6 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A quadratic high-gain DC-DC converter integrating a two-winding coupled inductor with low voltage stress on both switches for renewable energy applications. [PDF]

Sci Rep
Nadermohammadi A, Hosseini SH, Sabahi M.
europepmc   +1 more source

Defining and computing equivalent inductances of gapped iron core reactors

, 2012
The paper revisits the fundamental definitions and explores computational alternatives of equivalent inductances of gapped iron core reactors. Unlike in a transformer, the physical meaning of component inductances of a reactor is subject to uncertainty ...
Donuk, A., Rotaru, M., Sykulski, J.K.
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Analysis and research on iron loss of multi-layer interior permanent magnet synchronous motor for electric vehicle applications. [PDF]

Sci Rep
Niu L.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Research on Transmission Characteristics of Magnetic Couplers for Underwater Wireless Power Transfer Based on Prior Knowledge Input Neural Network. [PDF]

Sensors (Basel)
Xie J, Zhu C, Zhang X.
europepmc   +1 more source