Results 41 to 50 of about 173,398 (217)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Dispersion Characteristics of Complex Resistivity and Petroelectric Parameters of Deep Coal Seam in the Ordos Basin

Cejing jishu
The complex pore structure, metamorphic degree and mineral components have a great impact on the electrical conductivity characteristics of deep coal seams, posing significant challenges to the evaluation of saturation based on electrical parameters.
DENG Ze, ZHAO Qun, FAN liyong, GE Xinmin, HUANG Daojun, SHI Lei, WANG Ziming, ZHANG Yonghao   +7 more
doaj   +1 more source

Integrated petrophysical study to validate water saturation from well logs in Bahariya Shaley Sand Reservoirs, case study from Abu Gharadig Basin, Egypt

Journal of Petroleum Exploration and Production Technology, 2020
Water saturation is a key parameter in evaluating oil and gas reservoirs and calculating OIIP and GIIP for petroleum fields. The late Cretaceous Bahariya reservoir contains variable amounts of clay minerals.
Mohamed El-Bagoury
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

An Improved Method for Estimating the Saturation Magnetization and Core Size Distribution of Magnetic Nanoparticles Based on M-H Curve

IEEE Access
The saturation magnetization and core size distribution of magnetic nanoparticles (MNPs) play an important role in biomedical and biological applications. Fast and precise estimation of the saturation magnetization and core size distribution are critical.
Na Ye, Gaoli Zhao, Wenjie Wu, Pengchao Wang, Wenze Zhang, Zhongzhou Du   +5 more
doaj   +1 more source

A proposed solution to the determination of water saturation: using a modelled equation

Journal of Petroleum Exploration and Production Technology, 2018
Reservoir characterization is an important phase in oil and gas field development, which takes place during the appraisal phase of either a green field or a brown field upon which further development options are considered.
Jethro Sam-Marcus, Efeoghene Enaworu, Oluwatosin J. Rotimi, Ifeanyi Seteyeobot   +3 more
doaj   +1 more source