Results 101 to 110 of about 2,117,779 (343)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Stability of the Kauffman Model

open access: yes, 2001
Random Boolean networks, the Kauffman model, are revisited by means of a novel decimation algorithm, which reduces the networks to their dynamical cores.
Bilke, S., Sjunnesson, F.
core   +3 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Effect of an Eight-week Core Stability Training Program on the Functional Movement Screen Test Scores in Elite Goalball Players

open access: yesPhysical Treatments, 2021
Purpose: This study aimed to investigate the effect of eight weeks of core stability training on the functional movement screen (FMS) test scores in elite goalball players.  Methods: The study sample included 26 elite goalball players.
Azadeh Mahrokh Moghadam   +2 more
doaj  

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