Results 91 to 100 of about 410,180 (300)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Cores Symposium on Radiation in the Environment : Scientific Achievements and Challenges for the Society [PDF]

open access: yes, 2018
The Finnish Consortium for Radiation Safety Research (Cores) organized a symposium “Radiation in the environment – scientific achievements and challenges for the society” in Helsinki on April 16–17, 2018.
Lusa, Merja   +2 more
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Cambio de planes a través del tiempo para el traslado de roca en la pampa bonaerense

open access: yesEstudios Atacameños, 2004
Se analizan las formas de traslado de las materias primas líticas a partir de la comparación entre núcleos de momentos tempranos y tardíos en la pampa bonaerense argentina.
Cristina Bayón, Nora Flegenheimer
doaj  

Adecuaciones para mejorar la aplicación del método D3987-85 en la extracción de EPT de los antiguos residuos mineros El Fraile, Guerrero, México

open access: yesRevista Mexicana de Ciencias Geológicas, 2018
El método D3987-85 es uno de los procedimientos de lixiviación utilizados en el mundo para evaluar la peligrosidad de los jales de minas. El método ha sido oficializado en México en la Norma Oficial Mexicana NOM-141-SEMARNAT-2003; y durante su ...
Daniel Corrales-Pérez   +1 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Atomic scale models of dislocation cores in minerals: progress and prospects [PDF]

open access: yes, 2010
Recent advances in computer simulation at the atomic scale have made it possible to probe the structure and behaviour of the cores of dislocations in minerals.
A. M. Walker   +5 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

A asemblea das provincias galegas de 1922, o modelo mancomunalista e a autonomía integral de Galicia

open access: yesCuadernos de Estudios Gallegos, 1996
No ...
Baldomero Cores Trasmonte
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

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