Results 41 to 50 of about 163,458 (264)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

An Unusual Case of Nonhealing Granulomatous Keratitis Caused by Mycobacterium chelonae in a Healthy Middle Aged Adult

Case Reports in Ophthalmological Medicine, 2015
Purpose. To report a rare presentation of culture positive Mycobacterium chelonae (M. chelonae) corneal ulcer and its management. Case Report. We report a rare case with history of chronic pain and blurriness of vision.
Vipul Bhandari, Sriganesh, Kirti Relekar
doaj   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Persistent Lamellar Interface Fluid With Clear Cornea After Descemet Stripping Automated Endothelial Keratoplasty

, 2011
To describe clinical properties of a patient with persistent interface fluid syndrome and clear graft, 3.5 years after Descemet stripping automated endothelial keratoplasty (DSAEK). Case report.
Hurmeric, Volkan, Jianhua Wang, Sonia H Yoo, Yoo, Sonia H, Kymionis, George D, George D Kymionis, Wang, Jianhua, Volkan Hurmeric   +7 more
core   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Replication data for: "The Explicit Formula for the Hodrick-Prescott Filter in Finite Sample"

Cornea-Madeira, Adriana, (2017) "The Explicit Formula for the Hodrick-Prescott Filter in Finite Sample." Review of Economics and Statistics 99:2, 314 ...
Cornea-Madeira, Adriana
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Refractive Accuracy of a Novel Swept-Source OCT in Patients With Short and Long Eyes

Journal of Ophthalmology
Conclusions: The novel SS-OCT biometer using individual refractive indices to measure AL showed an overall good refractive accuracy using the BUII. The results were similar or better with the optimized BTAL formula, suggesting that formulas purposely ...
Laureano A. Rementería-Capelo, Inés Contreras, Jorge L. García-Pérez, Javier Ruiz-Alcocer   +3 more
doaj   +1 more source

Impact of a Mentoring Program in Cornea: Findings from a Qualitative Study of Participants

Purpose: A cornea mentorship program aims to increase the number of underrepresented in medicine physicians pursuing cornea fellowships in ophthalmology.
Hicks, Patrice, Montufar Wright, Parma E., Ahmed, Osama, Mike, Elise V., Woodward, Maria A., Armstrong, Mikhayla L., Woreta, Fasika, Marioneaux, Stephanie, Jeng, Bennie   +8 more
core   +1 more source