Results 161 to 170 of about 5,036,145 (299)

Diagnostic Utility of Full‐Length BP180 and Native BP180‐α6β4 Integrin Complex ELISAs in Serologically Inconclusive Mucous Membrane Pemphigoid

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial blistering disorder of mucosal surfaces that can cause irreversible scarring, blindness, or dysphagia. Early diagnosis is challenging because histopathology is nonspecific and conventional BP180 NC16A ELISAs have limited sensitivity.
Yukiko Ishizuka   +10 more
wiley   +1 more source

Mapping the lineage of prostate tissue ablation medical device predicates for focal therapy of prostate cancer approved via the FDA 510(k) clearance pathway

open access: yesSurgical Practice, EarlyView.
Abstract Objective Medical devices are reviewed by the US Food and Drug Administration (FDA) for safety and effectiveness. Class II devices can receive 510(k) clearance if they are “substantially equivalent” to an existing predicate device. This process can be repeated iteratively, leading to a lineage of predicates for newly cleared devices.
Yiting Lin   +3 more
wiley   +1 more source

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT We present three patients who developed allergic contact dermatitis (ACD) from benzalkonium chloride (BAK) in ophthalmic drops. BAK is a preservative commonly found in ophthalmic formulations and there is a rising trend of ACD to this allergen. The irritant and sensitising properties of BAK on the ocular mucosa will be discussed.
Arav Kannen   +2 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

open access: yesAndrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Interpreting the structure–function relationship in high myopia‐associated glaucoma: A review

open access: yesActa Ophthalmologica, EarlyView.
Abstract Visual field (VF) interpretation in high myopia‐associated glaucoma (HMG) is challenging due to frequent structure–function discordance and coexisting myopia‐related changes. These changes may reduce the reliability of conventional structure–function mapping and increase the risk of misclassifying non‐glaucomatous VF abnormalities as ...
Ruby S. Chan   +6 more
wiley   +1 more source

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