Results 231 to 240 of about 170,043 (285)

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Stromal Curvature, Power and Corneal‐Stromal Curvature Ratios From a Hybrid AS‐OCT in Eyes With Keratoconus

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To characterise stromal curvature and curvature ratios in keratoconus (KCN) using anterior segment OCT, and to evaluate the implications of using single‐, two‐, and three‐surface refractive models for corneal power estimation in ectatic eyes. Methods Retrospective observational study.
Jascha A. Wendelstein, Annabella Ostermaier, Katrin Freller, Arianna Grendele, Giacomo Savini, Catarina Praefke Coutinho, Robert Herber, Nikolaus Luft, Stefan Kassumeh, Achim Langenbucher, Siegfried Priglinger   +10 more
wiley   +1 more source

RETINA IS A TRENDING TOPIC IN OPHTHALMOLOGY

Vision Pan-America, 2017
Paulo E.C. Dantas
doaj   +1 more source

The Association among Corneal Nerve Metrics, Ocular Surface Integrity, and Renal Function in Type 2 Diabetes. [PDF]

Ophthalmol Sci
Liu C, Tan HC, Yu M, Lee IXY, Cheng CY, Liu YC.   +5 more
europepmc   +1 more source

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source

Lecithin-Cholesterol Acyltransferase Deficiency as a Rare Cause of Bilateral Corneal Opacities: A Case Report of a Novel Frameshift Mutation. [PDF]

Case Rep Ophthalmol
Mendes J, Mendes F, Fortunato DV, Garrido JV, Condesso R, Candeias A.   +5 more
europepmc   +1 more source

A Novel Homozygous Nonsense Pathogenic Variant of the CPAMD8 Gene Associated With Congenital Microcoria

Clinical Genetics, EarlyView.
A novel CPAMD8 nonsense mutation c.2679C>G (p.Tyr893*) was identified in a patient with congenital microcoria, leading to reduced mRNA expression and predicted protein truncation. ABSTRACT Congenital microcoria (MCOR) is a rare inherited ocular disorder. Here, we describe a novel nonsense variant in the CPAMD8 gene in a patient with MCOR.
Jing‐Fan Gao, Xin Jin, Jing‐Rao Wang, Shu Wang, Hong Zhang   +4 more
wiley   +1 more source

Quantitative Assessment of Visual Function in Japanese Patients With Lecithin-Cholesterol Acyltransferase Gene Abnormalities: A Case-Control Study. [PDF]

Cureus
Ono T, Iwasaki T, Sakisaka T, Mori Y, Nejima R, Miyata K.   +5 more
europepmc   +1 more source

Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma

Cell Proliferation, EarlyView.
Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the
Sicheng Bian, Jiangxia Cui, Xialin Zhang, Chongzhi Bai, Yanhong Tan, Zhuanghui Hao, Xingpeng Bu, Changxin Qu, Lili Sun, Leilei Lin, Qi Wang, Zhengrui Li, Xufeng Huang, Hengrui Liu, Ruo Wang, Yinghua Li, Hongwei Wang   +16 more
wiley   +1 more source

Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature

, 2016
Leopoldo Spadea, Emanuele Tonti, Enzo Maria Vingolo   +2 more
openalex   +2 more sources