Results 251 to 260 of about 9,423,348 (360)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Reduced Corneal Endothelial Cell Density in Patients With Dry Eye Disease [PDF]

open access: green, 2015
Ahmad Kheirkhah   +6 more
openalex   +1 more source

Test–Retest Reliability of Perception Threshold Estimation in Small Cutaneous Nerve Fibers: A Methodological Investigation

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Nerve excitability testing of small cutaneous nerve fibers has been proposed as a new tool for investigating the underlying mechanisms of small fiber neuropathy. These assessments may be performed using perception threshold tracking with pin‐electrodes that preferentially activate small cutaneous nerve fibers.
Helena Brøckner   +3 more
wiley   +1 more source

A simple and non-contact optical imaging probe for evaluation of corneal diseases [PDF]

open access: bronze, 2015
Xun Hong   +4 more
openalex   +1 more source

A Comprehensive Study of Quantum Dots: Ranging From Synthesis to Applications in Electrochemical Biosensors in the Detection of Biomolecules, Gastrointestinal Diseases, and Electrophysiology

open access: yesNano Select, EarlyView.
Quantum dots (QDs) typically refer to extremely small semiconductor particles, often no larger than 10 nm. The development of efficient biosensors for the sensitive and selective detection of biomolecules is essential for fundamental research in analytical chemistry, biomedicine, clinical diagnosis, and electrophysiology.
Parisa Navid   +2 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

open access: yesSmall, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa   +4 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

open access: yesSmall Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles(LNPs)and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu   +6 more
wiley   +1 more source

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