Results 21 to 30 of about 17,374 (135)

Costello Syndrome and Ophthalmologic Issues: Unveiling the Unseen

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is an ultra‐rare condition belonging to the RASopathies, a group of disorders characterized by aberrant RAS/MAPK pathway signaling, which is involved in ocular development and in some eye pathologies. However, only a few studies assessing the ophthalmic features of individuals with CS are available.
Sofia Peschiaroli, Germana Viscogliosi, Annabella Salerni, Emanuele Crincoli, Roberta Mattei, Tommaso Verdolotti, Serafina Antonella Loprete, Valentina Trevisan, Giovanni Antonio Marrocco, Alessia Cherubino, Lucrezia Perri, Roberta Onesimo, Giuseppe Zampino, Chiara Leoni   +13 more
wiley   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features

Chemistry &Biodiversity, EarlyView.
ABSTRACT A great deal of research has been carried out on the latex of Euphorbia resinifera Berg, which is an important source of several compounds of therapeutic and medicinal interest. Extraction, synthesis, and hemi synthesis pathways continue to reveal the existence of other new products with anticancer, antioxidant, antidiuretic, and antimalarial ...
Doaa Hammad, El‐Mahdi Ourhzif, Salha Hamri, Hafid Abderrafia, Mostafa Khouili, Maria Dolors Pujol   +5 more
wiley   +1 more source

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens, Anita Thyagarajan, Jeffrey B. Travers, Ravi P. Sahu   +3 more
wiley   +1 more source

Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea through Development

Journal of Biophotonics, EarlyView.
This paper investigates the geometrical and biomechanical properties of neonatal eyes at the early stages of development. We found that the corneal thickness is uncoupled from elastic wave speed and that the content and organization of the cornea primarily influence its mechanical properties.
Andrew L. Lopez III, Mohammad Dehshiri, Alexander W. Schill, Salavat Aglyamov, Kirill Larin   +4 more
wiley   +1 more source

Preclinical Testing of 3D Printed, Cell Loaded Hydrogel Based Corneal Substitutes on Rabbit Model

Macromolecular Bioscience, EarlyView.
This study reports on 3D‐printed methacrylated gelatin (GelMA) implants designed to serve as corneal stroma substitutes. The implants are characterized for their transparency, mechanical strength, and cytocompatibility. In vivo tests on rabbits demonstrate successful integration, with histopathological analysis showing tissue regeneration, appropriate ...
Deniz Basoz, Aslihan Akalinli, Senem Buyuksungur, A. R. Cenk Celebi, Deniz Yucel, Nesrin Hasirci, Vasif Hasirci   +6 more
wiley   +1 more source

Corneal Cell Matrix‐Conditioned Amniotic Membrane with Improved Biochemical Properties and Corneal Wound Healing Potential: An In Vitro and In Vivo Study

Macromolecular Materials and Engineering, EarlyView.
In this research, the amniotic membrane is sought to be enhanced biologically by treating it with primary cultured corneal cells. The findings indicate that amniotic membranes conditioned with limbal stem cells serve as an effective wound dressing that mimics corneal tissue, offering better cell adhesion, and healing properties, paving the way for ...
Zeinab Nokhbedehghan, Zahra Esmaeili, Seyed‐Hashem Daryabari, Hossein Aghamollaei, Sara Simorgh, Jila Majidi, Sanaz Alizadeh, Sadjad Khosravimelal, Narendra Pal Singh Chauhan, Hajar Nasiri, Mazaher Gholipourmalekabadi   +10 more
wiley   +1 more source

Thiol‐X Chemistry: A Skeleton Key Unlocking Advanced Polymers in Additive Manufacturing

Macromolecular Materials and Engineering, EarlyView.
Additive manufacturing and thiol‐X chemistry form a powerful combination for fabricating a diverse array of advanced polymers to address contemporary engineering applications. Thiol‐X reactions offer versatile polymerization mechanisms, “click” reactivity, functional group tolerance, desirable properties, and compatibility over a broad range of 3D ...
James Anthony Dicks, Chris Woolard
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity

Aging Cell, EarlyView.
The effect of advancing age and intraocular pressure injury on retinal ganglion cell function and synaptic connectivity. While young mice modulate their synaptic input to recover retinal ganglion cell function following injury, older mice compensate by altering their action potential threshold and axon initial segment (AIS) length to increase intrinsic
Vicki Chrysostomou, Sevannah Ellis, Lewis E. Fry, Robert J. Hatch, Eamonn T. Fahy, Katharina C. Bell, Ian A. Trounce, Peter van Wijngaarden, Steve Petrou, Jonathan G. Crowston   +9 more
wiley   +1 more source