Results 71 to 80 of about 726,771 (251)

Corneal stromal stem cells restore transparency after N2 injury in mice

Stem Cells Translational Medicine, 2020
Corneal scarring associated with various corneal conditions is a leading cause of blindness worldwide. The present study aimed to test the hypothesis that corneal stromal stem cells have a therapeutic effect and are able to restore the extracellular ...
Djida Ghoubay, Marie Borderie, Kate Grieve, Raphaël Martos, Romain Bocheux, Thu‐Mai Nguyen, Patrice Callard, Alain Chédotal, Vincent M. Borderie   +8 more
doaj   +1 more source

Corneal Densitometry in Keratoconus

, 2014
Purpose: The aim of this study was to compare corneal densitometry measured by Scheimpflug tomography in normal and keratoconic eyes and to assess the differences in densitometry values among the stages of keratoconus.Methods: Keratoconic and normal ...
Lopes, Bernardo [UNIFESP], Ambrosio, Renato [UNIFESP], Ramos, Isaac   +2 more
core   +1 more source

Anterior Segment Tomography with the Cirrus Optical Coherence Tomography [PDF]

, 2012
Optical coherence tomography (OCT) is an optical acquisition method to examine biological tissues. In recent years, OCT has become an important imaging technology used in diagnosing and following macular pathologies.
Rodrigues, Eduardo B. [UNIFESP], Fernando M. Penha, Eduardo B. Rodrigues, Johanson, Margara [UNIFESP], Penha, Fernando M. [UNIFESP], Margara Johanson   +5 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Birefringent properties of the human cornea in vivo : towards a new model of corneal structure [PDF]

The fundamental corneal properties of mechanical rigidity, maintenance of curvature and optical transparency result from the specific organisation of collagen fibrils in the corneal stroma. The exact arrangement of stromal collagen is currently unknown
Misson, Gary P.
core  

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Use of corneal allogenic intrastromal ring segments (CAIRS) in high astigmatism, a case report

American Journal of Ophthalmology Case Reports
Background: Corneal allogenic intrastromal ring segments (CAIRS) were developed as a biologic alternative to synthetic intracorneal ring segments and are primarily reported in the management of keratoconus and corneal ectasia.
Bader Khayat, Omar M. Alabbasi, Ghadi Aljohani   +2 more
doaj   +1 more source

Stem Cell Spheres for Corneal Regeneration

, 2021
Corneal cells isolated from the peripheral cornea and limbus can be cultured in vitro under sphere-forming conditions which enrich for stem and progenitor cells. These stem cell-enriched spheres represent a mixed population of cells comprising epithelial,
Li, Ye, Ismail, Salim, Huang, Stephanie U-Shane, McGhee, Jennifer J, Yoon, Jinny Jung, Sherwin, Trevor, Wadhwa, Himanshu, Mathan, Jeremy John   +7 more
core   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source