Results 101 to 110 of about 24,848 (319)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

open access: yesSmall, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa   +4 more
wiley   +1 more source

Beauty versus the beast: The UK public prefers less‐extreme body shapes in brachycephalic dog breeds

open access: yesVeterinary Record, EarlyView.
Abstract Background Brachycephalic dog breeds often exhibit a suite of extreme conformations linked with several severe and long‐term disorders. Despite this, ownership levels of brachycephalic breeds remain high internationally, with physical appearance being an important driver in their acquisition.
Elizabeth Youens   +6 more
wiley   +1 more source

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

open access: yesBMC Ophthalmology, 2012
Background Corneal ulceration leading to perforation is associated with infectious and non-infectious destructive conditions in the cornea. The fibrinolytic (plasminogen/plasmin) system is considered to contribute to tissue remodeling in the wound ...
Sugioka Koji   +5 more
doaj   +1 more source

Contact lens-related visual loss: A case series from Karachi [PDF]

open access: yes, 2011
All cases of corneal ulcers, presenting at the Aga Khan University Hospital, Karachi between January 2006 and December 2010 were reviewed. Information was obtained regarding socio-demography, the cause of ulcer, prior treatment and visual acuity ...
Ahmad, Khabir   +3 more
core   +1 more source

Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis [PDF]

open access: yes, 2015
PURPOSE: Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty.
Bonini, S.   +4 more
core   +4 more sources

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

open access: yesVIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou   +6 more
wiley   +1 more source

Characteristics and Predisposing Factors of Bacterial Corneal Ulcer in the National Eye Center, Cicendo Eye Hospital, Bandung from January to December 2011

open access: yesAlthea Medical Journal, 2015
Background: Corneal ulcer is an emergency condition in ophthalmology, causing visual impairment, mostly by bacterial infection with rapid pathogenesis. The aim of this study was to discover the characteristics of bacterial corneal ulcer patients in the ...
Astrid Maharani Putri   +2 more
doaj   +1 more source

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

open access: yesVIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang   +10 more
wiley   +1 more source

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