Results 81 to 90 of about 457,223 (336)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Acinetobacter junii as an aetiological agent of corneal ulcer

Infection, 2014
Rods of the Acinetobacter genus are present mainly in the external environment (e.g. water, soil) and in animals, while in humans they may comprise physiological flora.
G. Broniek, Ewa Langwińska-Wośko, Jerzy Szaflik, Marta Wróblewska   +3 more
semanticscholar   +1 more source

Exosome‐Loaded Contact Lenses: A Novel Approach for Sustained Ocular Drug Delivery

Nano Select, EarlyView.
The graphical abstract illustrates the characterization of the exosomes used, the loading technique, and the visual of the lens post‐exosome loading on the eye model. ABSTRACT Drug‐eluting permeable soft contact lenses are sustainable alternatives to traditional ocular drug delivery methods, such as topical eyedrops, ointments, gels, systemic delivery,
Said El Turk, Sarah Dhaiban, Nabila Yasmeen, Muaath Al Mansoori, Anna Maria Pappa, Abdulrahim Sajini, Haider Butt   +6 more
wiley   +1 more source

Repositioning of Pedicle Conjunctival Flap Performed for Refractory Corneal Ulcer

Middle East African Journal of Ophthalmology, 2014
A 50-year-old male was referred with a previous history of conjunctival flap (CF) for a nonhealing fungal corneal ulcer with extreme corneal thinning in the right eye. The peritomy for the CF extended from 6:30 to 9:30 clock h on the cornea.
A. Sharma, K. Mohan, Rajan Sharma, V. Nirankari   +3 more
semanticscholar   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

A case of canine cutaneous reactive histiocytosis over the body trunk in an adult pit bull terrier

Veterinary Record Case Reports, EarlyView.
Abstract The objective of this report is to present a case of canine cutaneous reactive histiocytosis with a high number of dendritic cells. A 7‐year‐old male pit bull terrier was presented with a 5‐month history of skin nodules and plaques on the trunk of varying diameter, along with corneal oedema and anterior uveitis.
Ioanna Papadogiannaki, Despoina Mourtzoukou, Konstantina Frangia, Emmanouil Papadogiannakis   +3 more
wiley   +1 more source

Pixelated pathologies: Camera trapping as a tool for monitoring wildlife health

Journal of Applied Ecology, EarlyView.
Given the increasing emergence of diseases, some with conservation and public health implications, improving and expanding wildlife health surveillance strategies is imperative. Camera trapping is particularly relevant for detecting new outbreaks, monitoring high‐risk zones and evaluating risk mitigation measures. Abstract Camera trapping has become an
Patricia Barroso, Pablo Palencia
wiley   +1 more source

Drug‐Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life‐threatening complications. Drug‐induced ocular adverse reactions are generally classified into two primary categories: toxic reactions ...
Andrea Leonardi, Banu Bozkurt, Diana Silva, Charlotte G. Mortz, Christophe Baudouin, Marina Atanaskovic‐Markovic, Vibha Sharma, Serge Doan, Shweta Agarwal, Daniel Pérez‐Formigo, Maria Joao Vasconcelos, Francoise‐Brignole Baudouin, Gonzalo Chorzepa, Jean‐Luc Fauquert, Virginia Calder, Pascal Demoly, Luis Delgado   +16 more
wiley   +1 more source

Characteristics and Predisposing Factors of Bacterial Corneal Ulcer in the National Eye Center, Cicendo Eye Hospital, Bandung from January to December 2011

Althea Medical Journal, 2015
Background: Corneal ulcer is an emergency condition in ophthalmology, causing visual impairment, mostly by bacterial infection with rapid pathogenesis. The aim of this study was to discover the characteristics of bacterial corneal ulcer patients in the ...
Astrid Maharani Putri, Susi Heryati, Nursiah Nasution   +2 more
doaj   +1 more source