Results 91 to 100 of about 18,499 (311)

Analysis of the pathogenic factors and management of dry eye in ocular surface disorders [PDF]

, 2017
The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin,
Albietz, Alio, Ambrosio, Djalilian, Dogru, Li, Nebbioso, Nebbioso, Patel, Rajan, Solomon, Suzuki, Toda, Wilson, Zhu   +14 more
core   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Simultaneous bilateral fungal keratitis caused by different fungi.

Indian Journal of Ophthalmology, 2002
Fungal keratitis is an important cause of corneal disease in the tropical world. We report a rare presentation of simultaneous bilateral corneal ulceration caused by different fungi.
Prajna Venkatesh, Rao Rema, Mathen Minu, Prajna Lalitha, George Celine, Srinivasan M   +5 more
doaj  

Exosome‐Loaded Contact Lenses: A Novel Approach for Sustained Ocular Drug Delivery

Nano Select, EarlyView.
The graphical abstract illustrates the characterization of the exosomes used, the loading technique, and the visual of the lens post‐exosome loading on the eye model. ABSTRACT Drug‐eluting permeable soft contact lenses are sustainable alternatives to traditional ocular drug delivery methods, such as topical eyedrops, ointments, gels, systemic delivery,
Said El Turk, Sarah Dhaiban, Nabila Yasmeen, Muaath Al Mansoori, Anna Maria Pappa, Abdulrahim Sajini, Haider Butt   +6 more
wiley   +1 more source

Keratoprostheses for corneal blindness: a review of contemporary devices [PDF]

, 2015
According to the World Health Organization, globally 4.9 million are blind due to corneal pathology. Corneal transplantation is successful and curative of the blindness for a majority of these cases. However, it is less successful in a number of diseases
Avadhanam, Venkata, Liu, Christopher, Smith, Helen   +2 more
core   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization [PDF]

, 2015
Background: To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI (protein with anti-inflammatory, anti-bacterial ...
Chuluyan, Hector Eduardo, Croxatto, Juan Oscar, Gallo, Juan Eduardo Maria, Guerrieri, Diego, Maffia, Paulo Cesar, Salica, Juan Pablo   +5 more
core   +2 more sources

Prevalence and Characteristics of Feline Ulcerative Keratitis and Corneal Sequestra in a Referral Population and Comparison Between Brachycephalic and Nonbrachycephalic Cats

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objectives To investigate the prevalence and characteristics of feline ulcerative keratitis (UK) and corneal sequestra (CS) in brachycephalic and nonbrachycephalic breeds. Animals Studied Brachycephalic and nonbrachycephalic cats. Procedures Cats diagnosed with UK or CS (Total, 392; UK, 290; CS, 102), between 2013 and 2022, were included ...
Moranne Frejlich, Guillaume Payen
openalex   +2 more sources

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

Spontaneous Corneal Hydrops in a Patient with a Corneal Ulcer

Case Reports in Ophthalmology, 2016
<b><i>Purpose:</i></b> We report the case of a 77-year-old man with no history of keratoconus or other ectatic disorders who presented with corneal hydrops in the setting of a corneal ulcer. The risk factors, pathogenesis and treatment options of corneal hydrops are discussed.
Hatim Batawi, Nikisha Kothari, Andrew Camp, Luis Bernhard, Carol L. Karp, Anat Galor   +5 more
openaire   +4 more sources