Results 51 to 60 of about 1,725,095 (289)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
The Impact of Upstream Static Deformation on Flow Past a Cylinder/Flare
AerospaceReynolds-averaged Navier–Stokes simulations are performed for supersonic turbulent flow over a cylinder/flare with upstream surface distortion representative of structural deformation induced via fluid–structural and fluid–thermal–structural behavior ...
Aaron Becks +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Energies, 2022 To deal with corner separation in high-load axial compressors, this paper proposes a new end wall contouring method aimed at controlling the end wall secondary flow in more than one local area, generating a geometry with fewer control variables that is ...
Fuhao You +4 more
doaj +1 more source
Research into Corner L Separable Assemblies in Storage Furniture
Drvna industrija, 2021 This research is based on the testing of the impact of the board (particleboard and medium density fiberboard (MDF)) and hardware type used to connect the sides and the bottom or top of the storage furniture on the joint strength. The hardwares of the following trade mark were used: the confirmat screw, Minifix, Maxifix, Stablofix, RV and Solo 32. Such
Župčić, Ivica +4 more
openaire +5 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Geometric Optimization of Coanda Jet Chamber Fins via Response Surface Methodology
AerospaceA highly loaded axial flow compressor often leads to significant flow separation, resulting in increased pressure loss and deterioration of the pressure increase ability.
Hui Zhang, Kai Yue, Yiming Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source