Results 51 to 60 of about 39,762 (260)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Corner separation control in compressor stators with jets from the blade leading edge

Advances in Mechanical Engineering, 2023
Corner separation occurs easily in highly loaded compressor stators. This paper proposes a novel slot inside the stator blade, with the slot inlet located at the blade leading edge and the slot outlet located at the suction surface, by using the momentum
Huan Zheng, Zhenggui Zhou
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Numerical Investigation into a New Method of Non-Axisymmetric End Wall Contouring for Axial Compressors

Energies, 2022
To deal with corner separation in high-load axial compressors, this paper proposes a new end wall contouring method aimed at controlling the end wall secondary flow in more than one local area, generating a geometry with fewer control variables that is ...
Fuhao You, Xiangjun Li, Qing Lu, Haoguang Zhang, Wuli Chu   +4 more
doaj   +1 more source

Shock-induced separated structures in symmetric corner flows [PDF]

Fluid Dynamics Conference, 1995
Three-dimensional supersonic viscous laminar flows over symmetric corners are considered in this paper. The characteristic features of such configurations are discussed and an historical survey on the past research work is presented. A new contribution based on a numerical technique that solves the parabolized form of the Navier-Stokes equations is ...
D'AMBROSIO, Domenic, MARSILIO, Roberto, PANDOLFI, MAURIZIO   +2 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Geometric Optimization of Coanda Jet Chamber Fins via Response Surface Methodology

Aerospace
A highly loaded axial flow compressor often leads to significant flow separation, resulting in increased pressure loss and deterioration of the pressure increase ability.
Hui Zhang, Kai Yue, Yiming Zhang
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Effects of contraction ratio on loss reduction of the flow in the reducing elbow duct with a weir-shaped obstacle

Journal of Fluid Science and Technology, 2023
90-degree elbow pipe/duct is one of the piping element which is used frequently in industrial apparatus. The separated flow which occurs at inner corner of elbow part and the secondary flow which occurs at the elbow and its downstream cause significant ...
Toshitake ANDO, Toshihiko SHAKOUCHI, Atsushi HANAI, Nobuyuki HAYASHI, Yohei FUKUTA, Koichi TSUJIMOTO, Mamoru TAKAHASHI   +6 more
doaj   +1 more source