An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin +18 more
wiley +1 more source
CLOCK 3111T/C Polymorphism and Sex Moderate the Effect of Childhood Trauma on White Matter Microstructure in Bipolar Disorder. [PDF]
Nozza F +10 more
europepmc +1 more source
Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang +15 more
wiley +1 more source
Electrostatic Doping of 2D Semiconductors Using Charged Dielectric Thin Films. [PDF]
Niu X +7 more
europepmc +1 more source
Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections
The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
wiley +1 more source
Development of Thermal Flash Heating/Rapid Cooling System Using a Heated Needle Coupled with an Alternating Current (AC) Corona Discharge Ion Source. [PDF]
Yamashita A +4 more
europepmc +1 more source
Ion‐Gating Reservoir Computing for Preprocessing‐Free Speech Recognition from Throat Vibrations
This work presents a throat‐mounted mechanoelectric sensor integrated with an ion‐gel/graphene reservoir device for on‐device speech recognition. The system converts raw biomechanical vibrations into rich nonlinear current dynamics, enabling efficient classification through a simple linear readout. The approach highlights a compact and tunable physical‐
Daiki Nishioka +5 more
wiley +1 more source
Surface charge engineering shields extracellular vesicles from plasma protein corona to enable systemic extrahepatic targeting. [PDF]
Tang T +16 more
europepmc +1 more source
Multiscale perspectives on how excess charges in soft lead halide perovskites induce operational instability in photovoltaic devices are presented. Localized carriers formed under thermodynamic non‐equilibrium states modify atomistic interactions and drive lattice distortions, accelerating device degradation.
Joo‐Hong Lee +6 more
wiley +1 more source

