Results 171 to 180 of about 5,956 (233)

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Preoperative Albumin Infusion Reduced Pulmonary Complications in Elderly Patients With Hypoalbuminemia Undergoing Cardiac Surgery: A Single‐Center, Randomized, Double‐Blind, Controlled Pilot Trial

MedComm, Volume 7, Issue 7, July 2026.
Elderly patients with preoperative hypoalbuminemia (< 40 g/L) undergoing cardiac surgery with cardiopulmonary bypass were randomized to receive 100 mL of 20% albumin or saline before surgery. Albumin infusion reduced the severity and incidence of PPCs and modulated immune balance.
Jie Liu, Shiqiang Chen, Yunxiao Bai, Yong Lv, Yanting Wang, Zhenzhen Xu, Nianguo Dong, Qingping Wu   +7 more
wiley   +1 more source

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE‐MAKE): A Protocol for a Pre‐Planned Sub‐Study of a Randomized Clinical Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Acute kidney injury (AKI) is a common and serious complication after cardiac arrest, affecting more than 30% of initially successfully resuscitated patients, with around 10% receiving Kidney Replacement Therapy (KRT). Currently, treatment options to prevent renal complications are limited.
Keski‐Keturi M, Niemelä V.H, Young P, Nielsen N, Wise M.P, Reinikainen M, Bass F, Lilja G, Dankiewicz J, Hammond N, Hästbacka J, Levin H, Moseby‐Knappe M, Saxena M, Tiainen M, Ceric A, Kamp C.B, Sillassen C.D.B, Alexandersson D, Schmidbauer S, Tirkkonen J, Oksanen T, Säkkinen H, Bendel S, Düring J, Lybeck A, Johnsson J, Unden J, Lundin A, Kåhlin J, Grip J, Lotman E, Romundstad L, Seidel P, Stammet P, Graf T, Mengel A, Leithner C, Nee J, Druwé P, Ameloot K, McGuigan P.J, White J, Govier M, Ostermann M, Hopkins P, Proudfoot A, Handslip R, Pogson D, Jackson P, Nichol A, Haenggi M, Hilty M.P, Iten M, Schrag C, Nafi M, Joannidis M, Robba C, Belohlavek J, Rob D, Arabi Y, Al‐Fares A, Yew Woon C, Aneman A, Stewart A, Arnott C, Ramanan M, Panwar R, Delaney A, Reade M, Venkatesh B, Taccone F, Pekkarinen P.T, Friberg H, Cronberg T, Jakobsen J.C, Skrifvars M.B   +76 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Agonist vs. Placebo and Pulmonary Decline After Open‐Heart Surgery: A Substudy of the GLORIOUS Randomised Clinical Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Postoperative pulmonary decline is an established complication of open‐heart surgery extending beyond the immediate postoperative phase. Inflammation‐mediated lung damage and ischaemia‐reperfusion injury secondary to extracorporeal circulation is a proposed pathophysiological driver. GLP‐1 receptor agonists (GLP‐1RA) have emerged as
Astrid Duus Mikkelsen, Sebastian Wiberg, Hans Henrik Lawaetz Schultz, Peter Hasse Møller‐Sørensen, Dan Høfsten, Jens Christian Nilsson, Christian Holdflod Møller, Lars Køber, Christian Hassager, Jesper Kjærgaard   +9 more
wiley   +1 more source

Longer Baseline Left Ventricular Activation Time Is Associated With Lower Mortality and Lower Risk of Heart Failure Hospitalization in Cardiac Resynchronization Therapy Recipients

Annals of Noninvasive Electrocardiology, Volume 31, Issue 4, July 2026.
In patients undergoing CRT implantation, a longer pre‐implant LVAT was linked to better clinical outcome (lower risk of heart failure hospitalization and all‐cause mortality), suggesting that LVAT may help refine risk stratification after CRT. ABSTRACT Introduction Many patients do not benefit from cardiac resynchronization therapy (CRT) with current ...
Sofia Marinko, Pyotr G. Platonov, Rasmus Borgquist   +2 more
wiley   +1 more source

Improvement of Health‐Related Quality of Life and Mental Health After Unilateral Adrenalectomy for Primary Aldosteronism

Clinical Endocrinology, Volume 105, Issue 1, Page 24-33, July 2026.
ABSTRACT Background Primary aldosteronism (PA) has been linked with reduced health‐related quality of life (QoL) and increased prevalence of anxiety and depression. While most studies compared patients with PA to healthy subjects, this study focused on comparison with hypertensive patients without PA to identify PA‐specific effects.
Sybille Fuld, Christian Adolf, Georgiana Constantinescu, Manuel Schulze, Denise Brüdgam, Carmina T. Fuss, Hanna Remde, Lydia Kürzinger, Sven Gruber, Jun Yang, Amy Kang, Martin Reincke, Felix Beuschlein, Graeme Eisenhofer, Jacques W. M. Lenders, Christina Pamporaki   +15 more
wiley   +1 more source

GLP‐1 Receptor Agonist Therapy and Cardiorenal Outcomes in Type 1 Diabetes: A Propensity‐Matched Real‐World Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6347-6357, July 2026.
ABSTRACT Aims Evidence on cardiovascular/renal outcomes associated with GLP‐1‐based therapies in type 1 diabetes (T1D) is limited. We examined the effects of GLP‐1‐based therapy on major clinical outcomes and safety, including diabetic ketoacidosis (DKA) and hypoglycemia risk, in adults with T1D in a large real‐world cohort.
Anastasios Tentolouris, Charalampos Filippatos, Nikolaos‐Iason Tepetes, Maria Gavriatopoulou, Evangelos Terpos, Alexandros Briasoulis, Kimon Stamatelopoulos, Theodosios Filippatos   +7 more
wiley   +1 more source

Visit‐to‐Visit Systolic Blood Pressure Variability Predicts Long‐Term Cardiovascular Events After Coronary Artery Bypass Grafting

The Journal of Clinical Hypertension, Volume 28, Issue 7, July 2026.
ABSTRACT This prospective observational study investigated whether systolic blood pressure variability (SBPV) during the transitional care period predicts long‐term outcomes after coronary artery bypass grafting (CABG). We enrolled 120 consecutive patients undergoing isolated CABG between 2020 and 2024 in a structured Transitional Care Service System ...
Pujuan Liu, Shang Wang, Huili Liu, Jing Wang, Man Zhang, Hong Shen, Sha Liu, Beibei Xing   +7 more
wiley   +1 more source

Prediction of incident heart failure in type 2 diabetes mellitus: Rationale and design of the DM‐HEART study

Journal of Diabetes Investigation, Volume 17, Issue 7, Page 1154-1162, July 2026.
ABSTRACT Preclinical heart failure (HF) (stages A and B) is common but easily overlooked in asymptomatic patients with type 2 diabetes (T2D). There is a paucity of evidence regarding how coexisting risk factors contribute to the development of HF in asymptomatic Asian patients with T2D, and there is a lack of guidance on the early identification of ...
Jiun‐Lu Lin, Yen‐Wen Wu, Sung‐Chen Liu, Chung‐Ming Tu, Heng‐Hsu Lin, Yi‐Fu Lin, Hao‐Yun Chang, Ming‐Nan Chien, Chih‐Yuan Wang, Chung‐Lieh Hung   +9 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources