Results 211 to 220 of about 47,449 (318)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave, June‐Chiew Han, Marie‐Louise Ward, Andrew J. Taberner, Kenneth Tran   +4 more
wiley   +1 more source

Postoperative Atrial Fibrillation Impacted by Completeness of Coronary Revascularization and Antiplatelet Regimen. [PDF]

Cardiovasc Ther
Jiang Q, Xie M, Yu Y, Tang Z, Xia J, Hu S.   +5 more
europepmc   +1 more source

On- vs. off-pump coronary artery bypass grafting: A systematic review and meta-analysis.

International Journal of Cardiology, 2016
G. Dieberg, N. Smart, N. King
semanticscholar   +1 more source

The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging

The Journal of Physiology, EarlyView.
Abstract figure legend This study examines the relationships between activation and repolarization times in epicardial reconstructed unipolar electrograms derived from ECG‐imaging in patients with normal and delayed ventricular activation. In patients with a narrow QRS‐complex, ECG‐imaging reveals significant variability in the activation ...
Karin C. Smits, Ted E.M. Lempers, Marc Strik, Job Stoks, Roel Meiburg, Matthijs J.M. Cluitmans, Paul G.A. Volders, Kevin Vernooy, Frits W. Prinzen, Uyên Châu Nguyên   +9 more
wiley   +1 more source

Central Aortic Cannulation for Total Coronary Revascularization via Anterior Thoracotomy: A Single-Center Initial Experience. [PDF]

J Cardiovasc Dev Dis
Demirkıran T, Taşöz Özdaş I, Işık Ökten G, Akyol FB, Özdem T, Tokgöz Y, Kekeçdil H, Kadan M, Karabacak K.   +8 more
europepmc   +1 more source

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Nationwide Trends in Coronary Artery Bypass Grafting in the Republic of Korea, 2005-2022: A Comparison with International Data. [PDF]

J Chest Surg
Ju MH, Lee JH, Kim YJ, Kim HJ, Hwang HY, Yeom SY, Kim HJ, Youn YN, Kim WS, Baek MJ, Chee HK, Korean Society for Coronary Artery Surgery.   +11 more
europepmc   +1 more source

Current outcomes of off-pump versus on-pump coronary artery bypass grafting: evidence from randomized controlled trials.

Journal of Thoracic Disease, 2016
D. Fudulu, U. Benedetto, Gustavo Guida Pecchinenda, P. Chivasso, V. Bruno, F. Rapetto, A. Bryan, G. Angelini   +7 more
semanticscholar   +1 more source