Results 151 to 160 of about 890,925 (294)

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe   +4 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

open access: yesBritish Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo   +4 more
wiley   +1 more source

Coronary Artery Bypass Grafting vs Percutaneous Coronary Intervention for Stable Multivessel Coronary Disease in the Current Era. [PDF]

open access: yesAnn Thorac Surg
DeFazio D   +7 more
europepmc   +1 more source

Clinical characteristics and in‐hospital mortality among insulin pump users with acute coronary syndrome in the predominantly open‐loop era: A UK‐wide MINAP registry analysis

open access: yesDiabetic Medicine, EarlyView.
Abstract Background We compared characteristics of adults with insulin‐treated diabetes using continuous subcutaneous insulin infusion (CSII) versus multiple daily insulin injections (MDI) during admission with acute coronary syndrome (ACS) and identified factors associated with in‐hospital mortality among CSII users.
Harshal Deshmukh   +6 more
wiley   +1 more source

Predictive Preoperative Score of Prolonged Mechanical Ventilation After Coronary Artery Bypass Grafting. [PDF]

open access: yesJ Clin Med
López-Lede A   +7 more
europepmc   +1 more source

Thirty‐day mortality among patients admitted due to acute myocardial infarction during the dates of the Cardiac Society of Australia and New Zealand Annual Scientific Meeting

open access: yesInternal Medicine Journal, EarlyView.
Abstract Patients admitted during major medical conferences may receive different care if there are significant staff shortages. We evaluated the mortality of patients presenting with acute myocardial infarction (AMI) according to whether they were admitted during the Cardiac Society of Australia and New Zealand (CSANZ) Annual Scientific Meeting (ASM).
Timothy Nathan Kwan   +8 more
wiley   +1 more source

Coronary artery bypass graft (CABG) and the diabetic patient: current perspectives

open access: yes, 2014
Darryl M Hoffman, Robert F Tranbaugh Division of Cardiothoracic Surgery, Beth Israel Medical Center, New York, NY, USA Abstract: Diabetes increases both the severity and the risks of coronary artery disease.
Hoffman DM, Tranbaugh RF
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