Revising NHE‐1: From Cardiac Homeostasis to Heart Failure and Future Drug Development
ABSTRACT NHE‐1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin‐1, and adrenergic pathways. In cardiac myocytes, NHE‐1 maintains pH homeostasis and couples to Na+/Ca2+ exchange and mitochondrial ion handling. During heart disease sustained activation drives
Vasileios Bouratzis +8 more
wiley +1 more source
The neglected second wound: a qualitative study of patients' experiences of lower limb vascular harvesting for coronary artery bypass grafting. [PDF]
Liu SY +5 more
europepmc +1 more source
Platelet FcɣRIIa Expression Refines Clinical Risk Assessment After Myocardial Infarction
ABSTRACT Background In patients with myocardial infarction (MI), quantifying expression of platelet FcɣRIIa (pFCG) stratifies risk of subsequent MI, stroke, and death. Aims Assess the prognostic implications of clinical risk alone and in combination with the pFCG test.
David J. Schneider +9 more
wiley +1 more source
Use of Aprotinin in a Patient With a Renal Transplant for Redo Coronary Artery Bypass Graft Surgery. [PDF]
Latif HMS.
europepmc +1 more source
ABSTRACT Background The European Society of Cardiology (ESC) guidelines for peripheral artery disease recommend antithrombotic strategies based on high ischemic risk (HIR) and high bleeding risk (HBR) criteria. However, their prognostic value in patients with lower extremity artery disease (LEAD) undergoing endovascular therapy (EVT) remains unclear ...
Hirokazu Shimono +8 more
wiley +1 more source
ABSTRACT Background Acute kidney injury (AKI) is associated with worse outcomes after percutaneous coronary intervention (PCI). Previous, smaller studies suggested nephroprotective effects of micro‐axial flow pump (mAFP) during PCI. This study aimed to compare renal outcomes of high‐risk PCI with mAFP or intraaortic balloon pump (IABP) support.
Elric Zweck +10 more
wiley +1 more source
Management of multiple sequential complications following coronary artery bypass grafting: a case report from Tanzania. [PDF]
Hassanali HM +6 more
europepmc +1 more source
ABSTRACT An 85‐year‐old man developed acute neurologic dysfunction, severe thrombocytopenia, microangiopathic hemolytic anemia, and ADAMTS13 activity of 4.6% after TMP‐SMX reexposure. Seven plasma‐exchange sessions plus corticosteroids produced rapid recovery.
Renee Morecroft +6 more
wiley +1 more source
Randomized Feasibility Trial of Routine Versus Selective Transesophageal Echocardiography During Isolated Coronary Artery Bypass Grafting. [PDF]
MacKay EJ +10 more
europepmc +1 more source
Outcomes of an Interventional Approach in STEMI and NSTEMI All‐Comer Octo and Nonagenarians
All‐cause mortality of an initial invasive strategy versus optimal medical treatment is assessed in 775 all‐comer consecutive (N)STEMI octo/nonagenarians. Nonagenarians were predominantly women, had lower hemoglobin levels, and eGFR. An invasive strategy treatment demonstrated lower 1 year mortality in octo/nonagenarian (N)STEMI patients, most ...
Charlotte E. P. Siegers +5 more
wiley +1 more source

