Results 281 to 290 of about 268,250 (362)

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Endothelial Activation and Stress Index-A Novel and Simple Prognostic Tool in Coronary Artery Bypass Grafting. [PDF]

J Clin Med
Krombholz-Reindl P, Vötsch A, Linni K, Seitelberger R, Gottardi R, Lichtenauer M, Hammerer M, Boxhammer E, Winkler A.   +8 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Post-Coronary Artery Bypass: The Power of Prognostic Nutritional Index in Determining Mortality. [PDF]

Anatol J Cardiol
Toprak B, Bilgiç A.
europepmc   +1 more source

Cardiovascular Morbidity in Patients Undergoing Successful Surgery for Primary Hyperparathyroidism

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Although previous studies have shown reduced cardiovascular events following parathyroidectomy (PTX), it is unclear whether this extends to contemporary patients diagnosed and treated with milder disease than previously. The aim of this nation‐wide study was to determine the effect on cardiovascular events after PTX, and to ...
Martin Nilsson, J. Gustav Smith, Mark Thier, Erik Nordenström, Anders Bergenfelz, Martin Almquist   +5 more
wiley   +1 more source

Effect of Cerebrolysin on Cognitive Function and Delirium in Coronary Artery Bypass Graft Patients. [PDF]

Med Sci Monit
Stadnik A, Jezierska M, Płotek W, Siwicka D, Mlak R, Dąbrowski W.   +5 more
europepmc   +1 more source

The impact of socio‐economic deprivation on the long‐term survival of people with diabetes and acute myocardial infarction: A nationwide cohort study

Diabetic Medicine, EarlyView.
Graphical Abstract summarising key study findings. Abstract Background People from areas of socio‐economic deprivation have poorer outcomes following acute myocardial infarction (AMI). How deprivation influences the survival of people with diabetes mellitus (DM) post‐AMI is not well described.
Nicholas Weight, Andrew Cole, Muhammad Rashid, Kamlesh Khunti, Shivani Misra, Evangelos Kontopantelis, Thomas A. Shepherd, Martin K. Rutter, Mamas A. Mamas   +8 more
wiley   +1 more source

Single incision right transaxillary robotic valve and coronary artery bypass grafting: a future therapy. [PDF]

Ann Cardiothorac Surg
Murtaza G, Badhwar V.
europepmc   +1 more source

Integrating gender medicine into modern healthcare: Progress and barriers

European Journal of Clinical Investigation, EarlyView.
Abstract Background Sex and gender are fundamental determinants of health, influencing disease risk, diagnosis, treatment, and outcomes across medical disciplines. While sex refers to biological characteristics, gender encompasses sociocultural dimensions, including behaviours and identities.
Rubén Fuentes Artiles, Caroline E. Gebhard, Catherine Gebhard   +2 more
wiley   +1 more source