Results 221 to 230 of about 511,877 (268)

Dual Targeting Approach Using 4‐Hydroxytamoxifen Neuropeptide Y Conjugates for Selective Addressing of Adipose Tissue

ChemMedChem, EarlyView.
The [F7,P34]‐pNPY based peptide‐drug conjugate targets the Y1 receptor and induces internalization. Once inside the cell, 4‐hydroxytamoxifen is cleaved from the peptide and is released into the cytosol, where it activates the estrogen receptor α. This dual‐targeting mechanism aims to promote body weight loss and offers a potential therapeutic strategy ...
Anna Kohler, Eva‐Maria Jülke, Luke C. Darveniza, Jan Stichel, Annette G. Beck‐Sickinger   +4 more
wiley   +1 more source

Early outcomes of hybrid coronary revascularization in multivessel coronary artery disease with low ejection fraction. [PDF]

Front Cardiovasc Med
Guz G, Avşar MK, Kırat B, Önsel İÖ, Yorgancılar D, Ateşeal S.   +5 more
europepmc   +1 more source

Impact of Antihypertensive Treatment on Outcomes of Adjuvant Bevacizumab for Ovarian Cancer (IATRO), Results from a Nationwide Emulated Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Antiangiogenic therapy with bevacizumab improves outcomes in ovarian cancer but induces hypertension, leading to major adverse cardiovascular events (MACE). While calcium channel blockers (CCBs) and angiotensin‐converting enzyme inhibitors (ACEi) are recommended for managing bevacizumab‐associated hypertension, their impacts on cancer progression and ...
Floriane Jochum, Élise Dumas, Joe‐Elie Salem, Stéphane Ederhy, Anne‐Sophie Hamy, Lise Lecointre, Enora Laas, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Paul Gougis   +10 more
wiley   +1 more source

Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease. [PDF]

JACC Adv
Kany S, Friedman SF, Al-Alusi M, Khurshid S, Rämö JT, Pipilas D, Pirruccello JP, Reeder C, Philippakis AA, Ho JE, Maddah M, Ellinor PT, Fahed AC.   +12 more
europepmc   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Cardiac Manifestations of Alkaptonuria: Aortic Valve Stenosis and Coronary Artery Disease in a 63-Year-Old Patient. [PDF]

JACC Case Rep
Solís Chávez MB, Montero Cruces L, Romiti S, Saiz-Pardo Sanz M, Maroto Castellanos LC.   +4 more
europepmc   +1 more source

Real‐World Edoxaban Concentrations in Older Patients Receiving Reduced‐Dose Regimens

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world edoxaban concentrations in older patients receiving reduced‐dose regimens. Low trough concentrations (< 12 ng/mL) were associated with an increased risk of thromboembolism. Among patients meeting the ELDERCARE‐AF criteria, low drug levels were more frequent with the 15 mg regimen than with the 30 mg regimen.
Sung‐Chun Tang, Shin‐Yi Lin, Chih‐Hao Chen, Yen‐Bin Liu, Li‐Ting Ho, Ching‐Hua Kuo, Yu‐Fong Peng, Chih‐Fen Huang, Jiann‐Shing Jeng   +8 more
wiley   +1 more source

The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis. [PDF]

Open Med (Wars)
Lian R, Zhang X.
europepmc   +1 more source

Hierarchical clustering of clinical and flow cytometry parameters is associated with deterioration in patients with community‐acquired pneumonia in the emergency department: A preliminary study

Cytometry Part B: Clinical Cytometry, EarlyView.
ABSTRACT Anticipating the evolution of septic patients with community‐acquired pneumonia (CAP) is challenging for front‐line physicians in the Emergency Department (ED). Prognosis depends mainly on early identification, antibiotics, organ support, but also immune status.
Thomas Lafon, Robin Jeannet, Thomas Daix, Guillaume Monneret, Jean Feuillard   +4 more
wiley   +1 more source