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The Role of Adipocytokines in Coronary Atherosclerosis
Current Atherosclerosis Reports, 2017The aim of this review is to overview the pathophysiological role of adipocytokines in atherogenesis, focusing on their potential role as biomarkers of coronary disease.Several lines of evidence indicated adipose tissue not only as depot but rather as an endocrine organ. In this context, the balance between pro- and anti-inflammatory adipocytokines has
L. Liberale +6 more
semanticscholar +5 more sources
Journal of the American Medical Association (JAMA), 1998
CONTEXT Although cholesterol-reducing treatment has been shown to reduce fatal and nonfatal coronary disease in patients with coronary heart disease (CHD), it is unknown whether benefit from the reduction of low-density lipoprotein cholesterol (LDL-C) in
J. Downs +9 more
semanticscholar +1 more source
CONTEXT Although cholesterol-reducing treatment has been shown to reduce fatal and nonfatal coronary disease in patients with coronary heart disease (CHD), it is unknown whether benefit from the reduction of low-density lipoprotein cholesterol (LDL-C) in
J. Downs +9 more
semanticscholar +1 more source
The neglected coronary atherosclerosis
Atherosclerosis, 1983A study of the natural history of coronary heart disease by means of gross inspection and light microscopy, carried out on 640 subjects aged 1-50 years who had died of violent accidents, revealed a grossly neglected coronary atherosclerosis. It included fibromuscular plaques, intimal necrotic areas and incorporated microthrombi present in the ...
C. Velican, Doina Velican
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Pharmacotherapy of coronary atherosclerosis
Expert Opinion on Pharmacotherapy, 2009Despite advances in the pharmacotherapy of atherosclerosis, the most successful agents used to treat this disease - statins - remain ineffective for the primary or secondary prevention of myocardial infarction in about two-thirds of patients. The lack of a more robust treatment effect underscores the limitations of lipid lowering alone and emphasizes ...
Renu Virmani +4 more
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Pathology of coronary atherosclerosis
Progress in Cardiovascular Diseases, 1971Abstract Histologic examination of coronary arteries reveals many features of pertinence. In infants, a new layer, the musculo-elastic layer, develops focally associated with thickening of the intima. Later in life, distinction of this normal process from pathologic states may be difficult. In cross sections, two types of lesions are seen: one purely
Jesse E. Edwards, Zeev Vlodaver
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Journal of the American Medical Association (JAMA), 2004
CONTEXT Statin drugs reduce both atherogenic lipoproteins and cardiovascular morbidity and mortality. However, the optimal strategy and target level for lipid reduction remain uncertain.
S. Nissen +11 more
semanticscholar +1 more source
CONTEXT Statin drugs reduce both atherogenic lipoproteins and cardiovascular morbidity and mortality. However, the optimal strategy and target level for lipid reduction remain uncertain.
S. Nissen +11 more
semanticscholar +1 more source
Dehydroepiandrosterone and Coronary Atherosclerosis
Annals of the New York Academy of Sciences, 1995Tissue culture, animal model, and epidemiologic studies suggest that dehydroepiandrosterone (DEHA) may inhibit atherosclerosis through its potent antiproliferative effects. To examine the relation between DHEA and a direct measure of coronary atherosclerosis, plasma DHEA, and DHEA sulfate (DHEAS) levels were determined in 206 middle-aged patients ...
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Progression of Coronary Atherosclerosis
New England Journal of Medicine, 1984Time, the severity of preexisting arterial stenosis, and coronary-artery surgery affect the progression of coronary atherosclerosis. As plaque formation worsens, the probability of acute obstruction increases significantly in medical and surgical patients.1 No clinical or laboratory risk factors consistently predict coronary arterial progression.
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Pathogenesis of Coronary Atherosclerosis
1984In the United States between 1974 and 1977, 52% of all causes of death were attributed to cardiovascular diseases {l}. By 1981 and 1982 this figure declined slightly to 49%. Since 1974 ischemic heart diseases have accounted for approximately 65% of all cardiovascular diseases and were responsible for every third death in the United States during this ...
S. David Gertz, Adi Kurgan
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Regression of Coronary Atherosclerosis
New England Journal of Medicine, 1990The study of therapeutic interventions to bring about the regression of atherosclerosis has been a major part of atherosclerosis research. Until recently, however, this objective had been realized only in experimental animal models. In the early part of this century, Anitschkow1 first demonstrated in a rabbit model of diet-induced atherosclerosis that ...
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