Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]
, 2018 Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W +23 more
core +2 more sources
Lipid Profiles and Prevalence of Dyslipidemia in Eastern Iranian Adolescents, Birjand, 2012
Iranian Journal of Medical Sciences, 2015 Background: Cardiovascular risk factors begin in childhood and adolescence. This study aimed at assessing serum lipids and prevalence of Dyslipidemia in 11-18 year old students of Birjand.
Fatemeh Taheri +5 more
doaj
Relationship Between Indices of Oxidative Stress, Endothelial Dysfunction and Chaperone Activity and the Severity of Coronary Atherosclerosis [PDF]
International Journal of Biomedicine, 2018 The aim of this research was to study the relationship between the indices of oxidative stress, endothelial dysfunction and chaperone activity of proteins with the severity of coronary atherosclerosis.
Julia A. Kotova +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam +7 more
wiley +1 more source
C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro [PDF]
, 2015 Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified.
Bianchi, Franca +9 more
core +1 more source
Prevalence of Dyslipidemia among Elementary School Children in Birjand, East of Iran, 2012
Journal of Tehran University Heart Center, 2016 Background: Various studies have indicated that dyslipidemia starts in childhood. There is a relationship between the concentration of blood lipids and atherosclerosis.
Fatemeh Taheri +5 more
doaj
The Prevalence of Traditional Cardiovascular Risk Factors in Low Socioeconomic Use individuals in Birjand 2008 (East IRAN) [PDF]
Journal of Cardio-Thoracic Medicine, 2015 Introduction : Studying the prevalence of cardiovascular risk factors in low socioeconomic groups is of great importance. People who are under the supervisioin and care of Imam Khomeini Relief Foundation are the most deprived in Iran.
Toba Kazemi +5 more
doaj
Transcriptome-wide association study reveals novel susceptibility genes for coronary atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 BackgroundGenetic risk factors substantially contributed to the development of coronary atherosclerosis. Genome-wide association study (GWAS) has identified many risk loci for coronary atherosclerosis, but the translation of these loci into therapeutic ...
Qiuping Zhao +8 more
doaj +1 more source
Diabetes and Subclinical Coronary Atherosclerosis
Diabetes & Metabolism Journal, 2018 It is well known that diabetic patients have a high risk of cardiovascular events, and although there has been a tremendous effort to reduce these cardiovascular risks, the incidence of cardiovascular morbidity and mortality in diabetic patients remains high. Therefore, the early detection of coronary artery disease (CAD) is necessary in those diabetic
Chang Hoon Lee +2 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.This study introduces the first miniaturized, patient‐specific carotid artery model created via 3D printing using GelMA with embedded vascular cells. Combining CFD, PIV, and flow perfusion, the model replicates anatomically dependent hemodynamics and cellular responses.
Jorge A. Catano +7 more
wiley +1 more source