Results 111 to 120 of about 5,529,262 (276)

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Differential Impact of Blood Pressure Control Targets on Epicardial Coronary Flow After Transcatheter Aortic Valve Replacement

Structural Heart
Background: The cause for the association between increased cardiovascular mortality rates and lower blood pressure (BP) after aortic valve replacement (AVR) is unclear. This study aims to assess how the epicardial coronary flow (ECF) after AVR varies as
Brennan J. Vogl, BS, Alejandra Chavez-Ponce, MD, Adam Wentworth, MS, Eric Erie, AAS, Pradeep Yadav, MD, Vinod H. Thourani, MD, Lakshmi Prasad Dasi, PhD, Brian Lindman, MD, MSc, Mohamad Alkhouli, MD, Hoda Hatoum, PhD   +9 more
doaj   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Improved detection of coronary artery disease by CZT regional coronary blood flow evaluation. [PDF]

Front Nucl Med, 2022
Lima RSL, Bezerra A, Andrade M, Domenico C, De Lorenzo A.   +4 more
europepmc   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Acute coronary syndrome: pathogenesis, diagnosis, treatment, rehabilitation (lecture 2)

КардиоСоматика, 2016
The lecture discusses the current methods of pain relief, inhibition of thrombus formation process in the coronary artery, restoring blood flow in the coronary artery and prevent it retrombosis in patients with acute coronary syndrome.
N. B Perepech
doaj  

Risk Factors of Suboptimal Coronary Blood Flow after a Percutaneous Coronary Intervention in Patients with Acute Anterior Wall Myocardial Infarction. [PDF]

J Pers Med, 2023
Maruszak N, Pilch W, Januszek R, Malinowski KP, Surdacki A, Chyrchel M.   +5 more
europepmc   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Some features of slow-flow coronary syndrome in patients with long-term inflammation

Евразийский Кардиологический Журнал
Introduction. The pathogenesis of slow flow coronary syndrome and its reversibility are not fully understood, which makes it difficult to treat these patients. Recently, there has been increasing evidence that inflammation plays a significant role in the
A. V. Voynov, O G. Zverev, S. M. Lazarev, L. I. Archakova, A. F. Bokov, O. P. Sokolova, M. A. Rogachevskaya   +6 more
doaj   +1 more source

Slow Coronary Blood Flow: Pathogenesis and Clinical Implications. [PDF]

Eur Cardiol, 2022
Aparicio A, Cuevas J, Morís C, Martín M.   +3 more
europepmc   +1 more source