Results 191 to 200 of about 5,529,262 (276)

Combined Intravenous Sildenafil and L-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow. [PDF]

Drugs R D, 2020
Brzezinski M, Dincheva GR, Alloo K, Wong C, Feng CM, Tom WL, Salahieh A, Wallace AW.   +7 more
europepmc   +1 more source

Maximum Allowable Contrast Dose and Risk of Acute Kidney Injury After Coronary Procedures

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Recent studies have questioned whether iodinated contrast is causally related to acute kidney injury (AKI). AIM We pursed a contemporary analysis to determine the impact of contrast dose on AKI following coronary procedures in an era of lower contrast doses and less nephrotoxic agents.
Harshita Gaba, Elise Mesenbring, Christine Chow, Jennifer A. Rymer, Celina M. Yong, Stephen W. Waldo, Jacob A. Doll   +6 more
wiley   +1 more source

Impaired Flow and Physiology in Coronaries With Anomalous Origin From the Opposite Sinus of Valsalva

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Anomalous Aortic Origin of a Coronary Artery (AAOCA) high‐risk anatomical features (intramural segment, acute take‐off angle, slit‐like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear.
Mauro Lo Rito, Mattia Squillace, Mauro Luca Agnifili, Antonio Rosato, Serena Anglese, Adele Chiavetta, Camilla Muritti, Miriam Deamici, Jessica Negri, Andrea Attanasio, Gianluigi Guida, Giandomenico Disabato, Francesco Secchi, Michele Conti, Alessandro Frigiola, Massimo Chessa, Alessandro Giamberti, Francesco Bedogni   +17 more
wiley   +1 more source

Spatial Mismatch Between Angiographic Obstruction and Plaque Destabilization in Acute Coronary Syndromes: A Conceptual Narrative Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The identification of the “culprit lesion” in acute coronary syndromes (ACS) traditionally relies on coronary angiography, assuming that the most severe stenosis, abrupt occlusion, or largest filling defect marks the site of plaque destabilization.
Fernando Quevedo‐Candela, Olivier F. Bertrand, Pedro Cepas‐Guillén, Jean‐Pierre Déry, David García‐Labbé, Andrés Ruhl, Eduardo Flores‐Umanzor, Tomas Cieza   +7 more
wiley   +1 more source

Balloon‐Stopper Retrieval and Peripheral Parking After Inadvertent Ostial Right Coronary Stent Deployment

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Percutaneous treatment of right coronary artery (RCA) ostial lesions is technically challenging due to cardiorespiratory motion. Case Summary We describe a 70‐year‐old man undergoing PCI for an ostial RCA lesion where a forceful cough caused complete stent expansion within the aortic root.
Fernando Quevedo‐Candela, Guy Proulx, Tomás Cieza   +2 more
wiley   +1 more source

Predictors of suboptimal coronary blood flow after primary angioplasty and its implications on short-term outcomes in patients with acute anterior STEMI. [PDF]

BMC Cardiovasc Disord, 2020
Elakabawi K, Huang X, Shah SA, Ullah H, Mintz GS, Yuan Z, Guo N.   +6 more
europepmc   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source