Results 311 to 320 of about 1,815,731 (375)

Haemodynamic consequences of acute pulmonary embolism predict risk of CTPA‐related acute kidney injury

open access: yesESC Heart Failure, EarlyView.
The graphical abstract summarizes that normotensive APE patients with elevated NT‐proBNP levels and higher BOVA scores are at increased risk of AKI and should be closely monitored for renal injury during hospitalization. Abstract Introduction Computed tomography pulmonary angiography (CTPA) is an important study in the diagnosis of acute pulmonary ...
Anna M. Imiela   +10 more
wiley   +1 more source

Phenotype characterization of heart failure with preserved ejection fraction in medical device and surgical trials

open access: yesESC Heart Failure, EarlyView.
This systematic review identified 24 clinical trials of medical device and surgical interventions for HFpEF, with 16 demonstrating at least safety and feasibility, but little evidence of long‐term benefit. Phenotype‐based responses suggest that certain interventions may benefit specific HFpEF subgroups, yet most trials suffered from heterogeneous ...
Kurdo Araz   +5 more
wiley   +1 more source

A pilot study on DNA methylation changes for non‐invasive molecular diagnostics in heart failure

open access: yesESC Heart Failure, EarlyView.
A liquid biopsy approach integrating the high‐resolution RRBS DNA methylation platform and network‐oriented strategy identified the hypomethylation of CPTA1, CKAP4, SPTB, SYT6, EIF2S2, and RAB11FIP1 genes as useful biomarkers in distinguishing between ischaemic and non‐ischaemic HF aetiologies.
Giuditta Benincasa   +7 more
wiley   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

open access: yesESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori   +9 more
wiley   +1 more source

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