Results 291 to 300 of about 1,305,157 (351)

SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

Animal Models and Experimental Medicine, EarlyView.
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling, Xilan Dong, Liyan Mao, Chengjun Huang, Linjing Cong, Haizeng Zhang, Jun Cai, Zhenzhen Chen   +7 more
wiley   +1 more source

Sex and Gendered Approach in Chronic Coronary Disease Guidelines: One Size Does Not Fit All. [PDF]

JACC Adv
Blazoski C, Kim YJ, Spitz J, Blumenthal RS, Sharma G.   +4 more
europepmc   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

Changes in hemodynamics of pulmonary artery using Flowire in a canine model of acute pulmonary thromboembolism

Animal Models and Experimental Medicine, EarlyView.
This study investigated changes in pulmonary artery hemodynamics using a Flowire catheter and evaluated the accuracy of Doppler echocardiography in dogs with acute pulmonary thromboembolism (PTE). Ten healthy beagles were anesthetized, and acute pulmonary hypertension (PH) was induced by injecting 300‐μm dextran microspheres.
Tomohiko Yoshida, Katsuhiro Matsuura, Akiko Uemura, Ryou Tanaka   +3 more
wiley   +1 more source

Surgical management of calcific valvular and coronary disease in a patient with alkaptonuria: a case report. [PDF]

Eur Heart J Case Rep
Boyd RM, Bharadwaj SN, Fagan A, Mehta CK.   +3 more
europepmc   +1 more source

Sheep femoral artery occlusion is well tolerated and does not result in ischemia

Animal Models and Experimental Medicine, EarlyView.
Left femoral artery occlusion (yellow arrows) can be seen shortly after the lateral femoral circumflex artery origin, with distal arterial reconstitution. Sheep with femoral artery occlusion showed no change in pain scores nor mobility, thus making them an appropriate model for novel small diameter femoral artery graft studies. Abstract Objective Sheep
Timothy Shiraev, Ziyu Wang, Lakshay Seth, Lisa Partel, Innes K. Wise, Hugh Paterson, John O'Sullivan, Sean Lal, Anthony S. Weiss, Paul Bannon, Robert D. Hume   +10 more
wiley   +1 more source

Long-Term Outcomes of Sex Differences in Three-Vessel Coronary Disease with Different Treatment Strategies: A Large Cohort Study. [PDF]

Glob Heart
Li J, Jiang L, Xu L, Tian J, Feng X, Wang D, Zhang Y, Hui R, Gao R, Song L, Yuan J, Zhao X.   +11 more
europepmc   +1 more source

Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System—A Multicenter Cohort Study in 163 Patients

Annals of Neurology, EarlyView.
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospective, observational cohort study, we analyzed 163 adult patients who met the diagnostic criteria for PACNS.
Anna Lena Fisse, Nadine Bonberg, Carolin Beuker, Claudia Pfeuffer, Andreas Heidenreich, Christina Krüger, Milani Deb‐Chatterji, Jana Becker, Stefan T. Gerner, Clemens Küpper, Louisa Nitsch, Roxane‐Isabelle Kestner, Lars Udo Krause, Juliane Herm, Alexander Katalinic, André Karch, Ralf Gold, Heinz Wiendl, Wolf‐Rüdiger Schäbitz, Gabor C. Petzold, Waltraud Pfeilschifter, Marius Ringelstein, Thorsten R. Doeppner, Lars Kellert, Hagen B. Huttner, Markus Kraemer, Tim Magnus, Karl Georg Haeusler, Heike Minnerup, Jens Minnerup   +29 more
wiley   +1 more source

Intramyocardial injection of hypoxia-conditioned extracellular vesicles increases myocardial perfusion in a swine model of chronic coronary disease. [PDF]

JTCVS Open
Harris DD, Sabe SA, Broadwin M, Stone C, Xu C, Kanuparthy M, Malhotra A, Abid MR, Sellke FW.   +8 more
europepmc   +1 more source

Reshaping Protein‐Based Nanoparticles: Innovative Artificial Intelligence‐Driven Strategies for Structural Design and Applications

Advanced NanoBiomed Research, EarlyView.
Artificial Intelligence‐driven advancements in protein‐based nanoparticle design enable exceptional functionalities, overcoming traditional challenges and expanding nanomedicine applications. Nanoparticles (NPs) have become a pivotal technology in biomedical research due to their unique physicochemical properties and nanoscale size, allowing for ...
Mohammad Mahmoudi Gomari, Mehdi Alidadi, Neda Rostami, Sidi A. Bencherif   +3 more
wiley   +1 more source