Results 51 to 60 of about 11,009,796 (379)

Machine Learning Framework to Identify Individuals at Risk of Rapid Progression of Coronary Atherosclerosis: From the PARADIGM Registry. [PDF]

, 2020
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk of RPP at a single point in time.
Al'Aref, Subhi J, Andreini, Daniele, Baskaran, Lohendran, Bax, Jeroen J, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Gransar, Heidi, Hadamitzky, Martin, Han, Donghee, Kim, Yong-Jin, Kolli, Kranthi K, Lee, Byoung Kwon, Lee, Sang-Eun, Leipsic, Jonathon A, Lin, Fay Y, Maffei, Erica, Marques, Hugo, Min, James K, Narula, Jagat, Pontone, Gianluca, Raff, Gilbert L, Samady, Habib, Shaw, Leslee J, Shin, Sangshoon, Stone, Peter, Sung, Ji Min, van Rosendael, Alexander R, Virmani, Renu   +35 more
core  

Impact of incomplete percutaneous revascularization in patients With multivessel coronary artery disease: a systematic review and meta-analysis [PDF]

, 2016
Background: Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients.
Bagur, Rodrigo, Berry, Colin, Curzen, Nick, De Belder, Mark, Kwok, Chun Shing, Large, Adrian, Ludman, Peter, Mamas, Mamas A., Matsukage, Takashi, Nagaraja, Vinayak, Nolan, James, Ooi, Sze-Yuan, Yoshimachi, Fuminobu   +12 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Effects of Sodium–Glucose Cotransporter 2 Inhibitors on Stage 4 Cardiovascular–Kidney–Metabolic Syndrome: A Propensity Score–Matched Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background This study investigated the effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on patients with stage 4 cardiovascular–kidney–metabolic syndrome over 1 year.
Tao Liu, Zeyuan Fan, Yuntao Li, Bing Xiao, Chang He   +4 more
doaj   +1 more source

Regeneration of the heart: from molecular mechanisms to clinical therapeutics

Military Medical Research, 2023
Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a huge public health burden.
Qian-Yun Guo, Jia-Qi Yang, Xun-Xun Feng, Yu-Jie Zhou   +3 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Prognostic impact of the atherogenic index of plasma in type 2 diabetes mellitus patients with acute coronary syndrome undergoing percutaneous coronary intervention

Lipids in Health and Disease, 2020
Background The association of the atherogenic index of plasma (AIP), an emerging lipid index that can predict the risk for cardiovascular disease, with adverse outcomes in type 2 diabetes mellitus (T2DM) patients with acute coronary syndrome (ACS ...
Xiaoteng Ma, Yan Sun, Yujing Cheng, Hua Shen, Fei Gao, Jing Qi, Lixia Yang, Zhijian Wang, Dongmei Shi, Yuyang Liu, Xiaoli Liu, Yujie Zhou   +11 more
doaj   +1 more source

Comparison of various insulin resistance surrogates on prognostic prediction and stratification following percutaneous coronary intervention in patients with and without type 2 diabetes mellitus

Cardiovascular Diabetology, 2021
Background Insulin resistance (IR), evaluation of which is difficult and complex, is closely associated with cardiovascular disease. Recently, various IR surrogates have been proposed and proved to be highly correlated with IR assessed by the gold ...
Qi Zhao, Yu-Jing Cheng, Ying-Kai Xu, Zi-Wei Zhao, Chi Liu, Tie-Nan Sun, Yu-Jie Zhou   +6 more
doaj   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source