Results 141 to 150 of about 170,980 (396)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization [PDF]

, 2016
Objectives The aim of this study was to compare microvascular resistance under both baseline and hyperemic conditions immediately after percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) with an unobstructed reference vessel in ...
Alamgir, Farquad, Cunnington, Michael S., Hoye, Angela, Ladwiniec, Andrew, Rossington, Jennifer, Thackray, Simon   +5 more
core   +1 more source

Nanostructured 316L Stainless Steel Stent Surfaces Improve Corrosion Resistance, and Enhance Endothelization and Hemocompatibility

Advanced Materials Interfaces, EarlyView.
This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan, Pelin Mutlu, Batur Ercan   +2 more
wiley   +1 more source

Coronary vasomotor tone during static and dynamic exercise [PDF]

, 2017
Coronary vasomotion is an important determinant of myocardial perfusion in patients with angina pectoris, and it influences not only normal but also stenotic coronary arteries.
Bortone, A., Eid, K., Gage, J. E., Grimm, J., Hess, O. M., Krayenbuehl, H. P., Nonogi, H.   +6 more
core  

Soft ULC Microgels at the Interface Interact and Flow as Hertzian‐Like Colloids

Advanced Materials Interfaces, EarlyView.
Monolayers of soft ULC microgels, studied combining interfacial rheology, AFM and computer simulations, exhibit isoelastic points. At these points, the measured stiffness of the monolayer remains constant despite large differences in particle concentration.
José Ruiz‐Franco, Tom Höfken, Maximilian M. Schmidt, Steffen Bochenek, Emanuela Zaccarelli, Andrea Scotti   +5 more
wiley   +1 more source

Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve [PDF]

, 2017
Background—Contrast fractional flow reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is more accurate than resting indices and does not require adenosine.
Berry, Colin, Choi, Dong-Hyun, De Bruyne, Bernard, Fearon, William F., Gould, K. Lance, Jeremias, Allen, Johnson, Nils P., Kobayashi, Yuhei, Nishi, Takeshi, Oldroyd, Keith G., Pijls, Nico H.J.   +10 more
core   +1 more source

Prognostic Value of Coronary Flow Reserve in Patients with Dialysis-Dependent ESRD.

Journal of the American Society of Nephrology, 2016
Capillary rarefaction of the coronary microcirculation is a consistent phenotype in patients with dialysis-dependent ESRD (dd-ESRD) and may help explain their excess mortality.
Nishant R. Shah, D. Charytan, V. Murthy, Hicham Skali Lami, V. Veeranna, M. Cheezum, V. Taqueti, Takashi Kato, C. Foster, J. Hainer, M. Gaber, J. Klein, S. Dorbala, R. Blankstein, M. D. Di Carli   +14 more
semanticscholar   +1 more source

Fractional Flow Reserve in Acute Coronary Syndromes ∗

Journal of the American College of Cardiology, 2016
The clinical utility of measuring fractional flow reserve (FFR) in the cardiac catheterization laboratory to guide the decision regarding coronary revascularization is now well established.
Nico H.J. Pijls, Bernard De Bruyne, William F. Fearon, William F. Fearon   +3 more
openaire   +3 more sources

Flow Analysis in Pathological Microvascular Models by Ultrasound Localization Microscopy

Advanced Materials Technologies, EarlyView.
This study presents a new platform combining ultrasound localization microscopy with biomimetic gelatin phantoms to analyze flow dynamics in small vessels with narrowing or obstructions. Using microbubble tracking, the method enables high‐resolution velocity mapping in 100–500 µm channels, revealing flow changes in pathological microvascular conditions
Yarin Gershman, Grigori Shapiro, Tamar Mano, Tali Ilovitsh   +3 more
wiley   +1 more source

Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study [PDF]

, 2017
Background: Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in patients with diabetes. Methods:
Adjedj, Julien, Barbato, Emanuele, Esposito, Giovanni, Fearon, William, Ferrone, Marco, Gargiulo, Giuseppe, Hennigan, Barry, Jeremias, Allen, Johnson, Nils, Matsumura, Mitsuaki, On behalf of the CONTRST Study Investigators, Stabile, Eugenio, Trimarco, Bruno, Zimmermann, Frederik   +13 more
core   +2 more sources