Results 81 to 90 of about 33,487 (265)

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Study of Coronary Sinus Flow Reserve Through Transesophageal Doppler Echocardiography in Normal Subjects

Arquivos Brasileiros de Cardiologia, 2002
OBJECTIVE - To evaluate the Coronary Flow Reserve in the Coronary Sinus through transesophageal Doppler echocardiography in normal subjects. METHODS - We obtained technically adequate flow samples for analysis in 10 healthy volunteers (37±8 years, 5 men)
José Ramos Filho, José A. F. Ramires, Marko Turina, Caio J. Medeiros, Mário Lachat, Jeane Tsutsui   +5 more
doaj   +1 more source

Coronary flow velocity reserve in hypertensive patients with left ventricular systolic dysfunction [PDF]

, 2002
Valéria Fontenelle Angelim Pereira, Clóvis de Carvalho Frimm, Ana Clara Tude Rodrigues, Jeane Mike Tsutsui, Mariana Cúri, Charles Mady, José Antônio Franchini Ramires   +6 more
openalex   +1 more source

Predictors of discordance between fractional flow reserve and resting full-cycle ratio in patients with coronary artery disease: Evidence from clinical practice [PDF]

, 2020
Yoshiteru Kato, Tomotaka Dohi, Yuichi Chikata, Tatsuya Fukase, Mitsuhiro Takeuchi, Norihito Takahashi, Hirohisa Endo, Hiroki Nishiyama, Shinichiro Doi, Iwao Okai, Hiroshi Iwata, Kikuo Isoda, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daida, Tohru Minamino   +15 more
openalex   +1 more source

1140 CLINICAL OUTCOME OF FRACTIONAL FLOW RESERVE GUIDED REVASCULARIZATION STRATEGY OF CORONARY LESIONS: THE HALE-BOPP STUDY [PDF]

, 2022
Serena Caglioni, Gianluca Campo, Francesco Gallo, Alessandra Scoccia, Alessandro Durante, Delio Tedeschi, Sebastiano Verdoliva, Bernardo Cortese, Ferruccio Bilotta, Stuart Watkins, Alfonso Ielasi, Giuliano Valentini, Marco Arena, Daniela Mele, Rita Pavasini, Matteo Serenelli, Graziella Pompei, Antonella Scala, Federico Gibiino, Ennio Scollo, Emanuele D ́aniello, Simone Biscaglia, Emanuele Barbato, Matteo Tebaldi   +23 more
openalex   +1 more source

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

Coronary flow reserve reduction in asymptomatic patients affected by systemic sclerosis [PDF]

, 2013
Alessia Faccini, Eustachio Agricola, Michele Oppizzi, Alberto Margonato, Maurizio Galderisi, M.G. Sabbadini, Stefano Franchini, Paolo G. Camici   +7 more
openalex   +1 more source

Impact of Plaque Components on Fractional Flow Reserve-Derived Computed Tomography in Severe Coronary Stenosis

, 2023
Toshimitsu Tsugu
openalex   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source