Results 321 to 330 of about 1,922,582 (395)

Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat

open access: yesBiopharmaceutics &Drug Disposition, EarlyView.
Coadministration of the xanthine oxidase inhibitor, febuxostat, delayed elimination of methotrexate, at least in part, by noncompetitive inhibition of human organic anion transporter 3‐mediated methotrexate transport at clinical concentrations. The findings of this study provide novel information on drug interactions associated with febuxostat ...
Kenji Ikemura   +3 more
wiley   +1 more source

Single‐component cationic polyethylenimine thermogel for sustained and localized gene delivery to combat multi‐drug resistant cancer

open access: yesBMEMat, EarlyView.
A cationic thermogelling copolymer employing branched PEI‐25 kDa as the sole hydrophilic segment can be facilely complexed with plasmid by physical mixing in the sol phase. Spontaneous gelation is achieved via self‐assembly after injection due to physiological temperature. Sustained and localized release of plasmid from the cationic PEI‐thermogel leads
Qianyu Lin   +11 more
wiley   +1 more source

Absolute impact of lipid levels on coronary heart disease in a real-world primary prevention cohort of 730,236 people. [PDF]

open access: yesAm J Prev Cardiol
Alves-Cabratosa L   +12 more
europepmc   +1 more source

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