Results 191 to 200 of about 96,509 (260)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Non-chest pain symptoms and likelihood of coronary occlusion in emergency department patients with ST segment elevation undergoing emergent coronary angiography. [PDF]

Coron Artery Dis
Ma Z, Antoine MK, Vefali H, Manda Y, Salen P, Shoemaker M, Stoltzfus J, Puleo P.   +7 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Impact of a Chronic Total Coronary Occlusion on the Incidence of Appropriate Implantable Cardioverter-Defibrillator Shocks and Mortality: A Substudy of the Dutch Outcome in ICD Therapy (DO-IT)) Registry. [PDF]

J Am Heart Assoc
van Veelen A, Verstraelen TE, Somsen YBO, Elias J, van Dongen IM, Delnoy PPHM, Scholten MF, Boersma LVA, Maass AH, Strikwerda S, Firouzi M, Allaart CP, Vernooy K, Grauss RW, Tukkie R, Knaapen P, Zwinderman AH, Dijkgraaf MGW, Claessen BEPM, van Barreveld M, Wilde AAM, Henriques JPS, DO‐IT investigators *.   +22 more
europepmc   +1 more source

Cardiovascular–Kidney–Metabolic Syndrome Severity and Risk of Pancreatic Cancer in a Large Prospective Cohort

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims Pancreatic cancer remains one of the most lethal malignancies due to late diagnosis and limited opportunities for prevention. Cardiovascular–kidney–metabolic (CKM) syndrome reflects the cumulative burden of metabolic, renal, and cardiovascular dysfunction, but its association with pancreatic cancer risk has not been well established.
Munseok Choi, Seok‐Jae Heo, Yu‐Jin Kwon, Chang Moo Kang   +3 more
wiley   +1 more source

Deferred Cytoreductive Nephrectomy With Partial Hepatectomy for Giant Renal Cell Carcinoma of the Right Kidney With Extensive Hepatic Invasion: A Case Report in the Era of Systemic Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Deferred cytoreductive nephrectomy may improve the prognosis of patients with metastatic renal cell carcinoma (RCC). However, reports of combined hepatic resection for RCC with liver invasion are limited, and treatment strategies remain insufficiently established.
Yuki Hiroshi, Takamitsu Inoue, Takuya Minagawa, Masaki Takahashi, Akinobu Katami, Mizuki Onozawa, Masahiro Shinoda, Osamu Itano, Jun Miyazaki   +8 more
wiley   +1 more source

Individual and Combined Cardioprotective Effects of 1,25(OH)2D3 and Dimethyl Fumarate in an Isoproterenol‐Induced Myocardial Injury Model

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
1,25(OH)2D3 and dimethyl fumarate, administered alone or in combination, provide significant cardioprotection against isoproterenol‐induced myocardial injury by reducing oxidative stress, inflammation, and structural damage through modulation of the Nrf2/NF‐κB signaling pathways and the renin–angiotensin system (RAS).
Fatma Hande Karpuzoğlu, Serhat Kilinç, İlayda Sözmen, İlknur Bingül, Abdurrahman Fatih Aydin, Aysel Bayram, Semen Önder, Efe Akçe, Semra Doğru‐Abbasoğlu, Müjdat Uysal   +9 more
wiley   +1 more source

The Effects of Remote Ischemic Preconditioning on the Inflammatory Cytokine Response to Free Flap Head and Neck Reconstruction: A Randomized Controlled Trial

Microsurgery, Volume 46, Issue 6, September 2026.
ABSTRACT Introduction Ischemia–reperfusion injury due to vascular pedicle occlusion is one of the most common causes of free flap failure in head and neck cancer reconstruction. Remote ischemic preconditioning (RIPC) has been proposed as an experimental, non‐invasive intervention to attenuate flap ischemia–reperfusion injury; however, the tissue ...
Kumanan Rune Nanthan, Julie Brogaard Larsen, Christine Lodberg Hvas, Birgitte Jul Kiil, Andreas Engel Krag   +4 more
wiley   +1 more source