Results 41 to 50 of about 850,055 (258)

Novel Drug‐Testing Platform for Vascular Injury‐induced Intimal Hyperplasia Using a Microphysiological System

Advanced Healthcare Materials, EarlyView.
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam, HyeMi Kim, Jeong Ah Kim, Ki‐Hwan Nam, Kye‐Sung Lee, Hwan Hur, Jessie S. Jeon, Ji Yong Bae   +7 more
wiley   +1 more source

Relationship between left coronary artery bifurcation angle and restenosis after stenting of the proximal left anterior descending artery

Coronary Artery Disease, 2016
IntroductionRestenosis after a percutaneous coronary intervention for proximal left anterior descending (pLAD) coronary artery disease remains a clinical challenge. However, the relationship between the left main trunk (LMT)/LAD bifurcation angle and the
T. Konishi, Tadashi Yamamoto, Naohiro Funayama, H. Nishihara, D. Hotta   +4 more
semanticscholar   +1 more source

Everolimus‐Coated Laser‐Cut Self‐Expandable Metallic Stent Suppresses Stent‐Induced Tissue Hyperplasia in a Rat Gastric Outlet

Advanced NanoBiomed Research, EarlyView.
Everolimus‐coated laser‐cut self‐expandable metallic stents suppress stent‐induced tissue hyperplasia in the gastric outlet by reducing inflammation, fibrosis, and smooth muscle proliferation. Herein, we demonstrate the mechanical stability, sustained drug release, and histological benefits in a rat gastric outlet model, suggesting potential for ...
Yubeen Park, Chae Eun Yun, Dong‐Sung Won, Song Hee Kim, Ji Won Kim, Seung Jin Eo, Seokin Kang, Hyun‐Do Jung, Do Hoon Kim, Jun‐Kyu Park, Jung‐Hoon Park   +10 more
wiley   +1 more source

Restenosis after directional coronary atherectomy

Journal of the American College of Cardiology, 1992
This study evaluates the incidence of restenosis after successful directional coronary atherectomy and identifies risk factors for restenosis.Directional coronary atherectomy has been shown to be a safe and effective treatment of obstructive coronary artery disease; however, information regarding restenosis is limited.Between October 1986 and December ...
Dennis J. Sheehan, John B. Simpson, James W. Vetter, Tomoaki Hinohara, Matthew R. Selmon, Lissa J. Braden, Gregory C. Robertson, M. Rowe, Bruce J. McAuley   +8 more
openaire   +3 more sources

Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System as Risk Factors for the Development of In-Stent Restenosis in Patients with Stable Coronary Artery Disease

Biomolecules, 2021
This study investigated the renin-angiotensin-aldosterone system (RAAS) gene polymorphisms as possible genetic risk factors for the restenosis development in patients with drug-eluting stents.
Madina Azova, Kalima Timizheva, Amira Ait Aissa, Mikhail Blagonravov, Olga Gigani, Anna Aghajanyan, Leyla Tskhovrebova   +6 more
doaj   +1 more source

MEW/PVA‐MA Hydrogel Vascular Grafts: Enhancing Hemocompatibility and Endothelialization

Advanced NanoBiomed Research, EarlyView.
A biomimetic vascular graft combining biofunctionalized PVA‐MA hydrogels with a MEW scaffold is developed for small‐diameter applications. Gel‐MA and Hep‐MA incorporation enhances endothelialization and hemocompatibility, respectively, targeting the acute biological responses.
Verena Kronberger, Shouyuan Jiang, Minh H. Ho, Jasneil Singh, Chung‐Wei (Roy) Hsu, Gabriella C. J. Lindberg, Khoon S. Lim, Tomasz Jungst, Anna Waterhouse   +8 more
wiley   +1 more source

Experimental models of coronary artery restenosis

Journal of the American College of Cardiology, 1992
The study of potentially effective drug therapies and mechanical devices for the prevention of restenosis after percutaneous coronary revascularization has relied heavily on the use of experimental animal models. To date, greater than 50 experimental studies have been reported and have suggested that at least nine different classes of pharmacologic ...
David W.M. Muller, Stephen G. Ellis, Eric J. Topol   +2 more
openaire   +3 more sources

Restenosis pathophysiological mechanisms and genetic markers after percutaneous coronary interventions

Кардиоваскулярная терапия и профилактика, 2007
Coronary restenosis remains the main problem for effectiveness of percutaneous transluminal coronary angioplasty (PCA) and coronary stenting (CS). The aim of this review is to analyze pathogenetic mechanisms of coronary restenosis after PCA and CS, as ...
Yu. A. Shuvalova, A. N. Meshkov, A. I. Kaminny, G. F. Piksina, V. V. Kukharchuk   +4 more
doaj  

Use of drug-coated balloon instead of drug-eluting stent for pediatric cardiac allograft vasculopathy

Annals of Pediatric Cardiology, 2023
Cardiac allograft vasculopathy (CAV) sometimes leads to restenosis, even after percutaneous transcatheter intervention. Recently, drug-coated balloons (DCBs) have been successfully used to treat coronary artery disease, especially CAVs, in adults ...
Masaki Hirose, Jun Narita, Kazuhisa Hashimoto, Ryo Ishii, Hidekazu Ishida, Keiichi Ozono   +5 more
doaj   +1 more source

Intravascular Ultrasound Findings Associated With Hydrodynamic Contrast Recanalization (HDR) of Coronary Chronic Total Occlusions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Hydrodynamic contrast recanalization (HDR) is a novel technique to facilitate wire crossing during chronic total occlusion (CTO) percutaneous coronary interventions (PCI). The mechanisms underlying HDR have not been fully described.
Salman A. Arain, Angelo Nascimbene, Akshitha Yarrabothula, Jaime Hudson, Emmanouil S. Brilakis, Antonio Colombo, Lorenzo Azzalini, M. Bilal Iqbal, Bernardo Cortese, Yukata Tadano, Tsutomu Fujita, Mauro Carlino, Biswajit Kar   +12 more
wiley   +1 more source