Results 181 to 190 of about 1,823,543 (375)
This study evaluates the role of elastin in vascular response 28 days after balloon angioplasty using uncoated and paclitaxel‐coated balloons in a healthy porcine model. The results show higher elastin content in external femoral arteries, which is inversely correlated with vascular injury, inflammation, smooth muscle cell loss, proteoglycan and fibrin
María Gracia de Garnica García+7 more
wiley +1 more source
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling+7 more
wiley +1 more source
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
A light‐induced transfection system (LITS) was designed to precisely control the delivery of mRNA, achieving spatiotemporal de‐coupling of the pleotropic inflammatory and tolerogenic signals of interleukin‐2 to conduct safe eradication of tumors. Abstract Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA ...
Pengwen Chen+7 more
wiley +2 more sources
Contractile responses of canine coronary collateral vessels.
Hozuka Akita+2 more
openalex +2 more sources
Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang+5 more
wiley +1 more source