Results 201 to 210 of about 147,356 (246)

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, EarlyView.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

Murray Law-Based Quantitative Flow Ratio Proficiency in Clinical Practice: Validating Routine Diagnostic Performance and Analyzing Learning Curve Thresholds. [PDF]

J Am Heart Assoc
Deng D, Feng Y, Zeng M, Chen S, Qin H, Chen Y, Li L, Zhu J, Wan C, Gao H, Liu F, Yi D, Luo W, Hau WK, Tu S, Zhang Z.   +15 more
europepmc   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

"Vox Populi" Fractional Flow Reserve (vpFFR)-Leveraging Wisdom of the Crowd for the Assessment of Hemodynamic Severity of Intermediate Coronary Lesions. [PDF]

Diagnostics (Basel)
Odanovic N, Misevic V, Obradovic A, Bojic V, Krupnikovic K, Mandic A, Furtula M, Borzanovic D, Lazarevic N, Zivkovic S, Ilic I, Dobric M, Shah SM.   +12 more
europepmc   +1 more source

Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis

Precision Medical Sciences, EarlyView.
Central illustration: Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement. Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis.
Muhammad Huzaifa Ahmed Khan, Muneeb Khawar, Asad Ullah Farooq, Azooba Khalid, Syed Muhammad Ahsan, M. Hamza Naseer Awan, Muhammad Soban Nisar, Asim Elahi, Muhammad Aqib Faizan, Iqra Shahid, Abdullah Munir Ahmed, Faseeh Haider, Rejina Chhetri   +12 more
wiley   +1 more source

Coronary Physiology Across the Whole Spectrum of Ischemic Heart Disease. [PDF]

J Clin Med
Pollio Benvenuto C, Cappannoli L, Viceré A, Viccaro V, Todisco S, Giuliana C, Sharif F, Galante D.   +7 more
europepmc   +1 more source

Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio: A Systematic Review and Meta-Analysis. [PDF]

Med Sci (Basel)
Huang G, Ge P, Zhu H, Han S, Shi L.
europepmc   +1 more source

Surgical management of coronary-cameral fistula with aneurysmal right coronary artery. [PDF]

J Surg Case Rep
Li Y, Liu L, Yu F.
europepmc   +1 more source

Therapeutic Impact of Dobutamine Stress Echocardiography in Chronic Coronary Syndrome: A Real-World Monocentric Study in a Moroccan Population. [PDF]

Cureus
Bennis G, Hafid S, Lebbar MS, Daoudi Y, Alaoui Yazidi M, Taibi OM, Rabii H, Kheyi J, Merzouk F, Benouna G.   +9 more
europepmc   +1 more source