Results 41 to 50 of about 11,555 (279)

A Komnenos Mosaic in Hagia Sophia: On Its Dating and Iconology

open access: yesSanat Tarihi Yıllığı, 2023
This paper presents an examination of the Komnenos mosaic in the south gallery of Hagia Sophia by focusing on its dating and iconography. The mosaic often dates to, around 1122 and depicts Byzantine Emperor John II Komnenos, Empress Irene, and their son,
Yavuz Erdihan
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Ferdinand I. und seine erste Begegnung mit dem Königreich Böhmen und Prag 1527 im Spiegel der zeitgenössischen Flugblätter und Flugschriften / Ferdinand I and his first encounter with the Kingdom of Bohemia and Prague in 1527 in the mirror of the period leaflets [PDF]

open access: yesHistorie - Otázky - Problémy, 2015
The author examines leaflet publicity and the relationship between Ferdinand I and the city of Prague. Her prime focus is on most of German leaflets concerning the journey of Ferdinand and Anne Jagiello from Vienna to Prague (1527), acceptance of the ...
Jana Hubková
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Carolingian Traditions and New Beginnings : The Coronation of Rudolph I of Upper Burgundy

open access: yesBulletin du Centre d’Études Médiévales d’Auxerre, 2018
Cet article vise à éclairer les débuts du royaume de Bourgogne qui naît en 888 aux bords du lac Léman et à mieux comprendre l’essor de la dynastie régnante.
Andrea Hauff
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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