Results 161 to 170 of about 644,114 (233)

Coronavirus Exploitation of Ubiquitination and Selective Autophagy to Control Innate Immunity: Mechanisms, Systems Logic, and Therapeutic Opportunities. [PDF]

Viruses
Wang P, Zhao Y, Yang Y, Zhang J, Wu J, Wang J.   +5 more
europepmc   +1 more source

“Thinking Out Loud” and “Pivoting on the Fly”—An Empirical Review and Critical Incident Study of How Physicians Engage in Incidental Learning Amidst Complexity

Human Resource Development Quarterly, EarlyView.
ABSTRACT This study explores incidental learning among physicians navigating uncertainty during the COVID‐19 pandemic. Using a constructivist research design, we conducted a literature review of 13 empirical studies on incidental learning in complexity and analyzed critical incident interviews with 12 emergency medicine and intensive care physicians ...
Henriette Lundgren, Karen E. Watkins, Victoria J. Marsick, Dimitrios Papanagnou, Urvashi Vaid   +4 more
wiley   +1 more source

Outcomes Following Pancreatoduodenectomy With Arterial Resection: A NSQIP Analysis Comparing Trends in Patient Selection and Outcomes to Venous or no Vascular Resection Over 5 Years

International Journal of Cancer, EarlyView.
ABSTRACT Evaluation of arterial resection (AR) during pancreatoduodenectomy (PD) remains limited. This study compares PD with AR to PD with venous resection (VR) and no vascular resection (NVR). Patient demographics, outcomes, and changes over 5 years are evaluated.
Kevin Verhoeff, Alynne Kris Ribano, Daniel Kilburn, Carol‐Anne Moulton, Chaya Shwaartz, Trevor Reichman, Ian McGlivray, Sean Cleary   +7 more
wiley   +1 more source

Transcription Regulatory Sequences in Coronaviruses: Mechanistic Foundations for Antivirals and Vaccines. [PDF]

J Microbiol Biotechnol
Myoung J.
europepmc   +1 more source

Vaccinations in pregnancy: An update for a changing time

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Maternal immunization is one of the most effective public health interventions to reduce infectious morbidity and mortality in pregnant women, fetuses, and newborns. Despite robust evidence supporting vaccine safety and effectiveness in pregnancy, global uptake has declined following the COVID‐19 pandemic, contributing to resurgent outbreaks ...
Wendy Hodge, Méabh Bhuinneáin, Gelila Goba, Marisa Labovsky, Eliana Amaral, Asma Khalil, David Lissauer, Hema Divakar, Fionnuala M. McAuliffe, Deborah Money, Dharmintra Pasupathy, on behalf of the FIGO Committee on Infections During Pregnancy   +11 more
wiley   +1 more source

IRE1α Is Associated with Host Lipid Biosynthesis During Human Coronavirus OC43 Infection. [PDF]

Viruses
James KN, Miller JA, Huston HC, Oda JM, Fink SL.   +4 more
europepmc   +1 more source

Multi‐omics reveals gastrointestinal metabolic disorder‐induced diarrhea in postpartum dairy cows

iMetaOmics, EarlyView.
Nutritional diarrhea is a pervasive, costly challenge in dairy production. Using integrated metagenomic and metabolomic profiling, we identified coordinated microbial and metabolic alterations across the rumen, hindgut, and serum. In the rumen, enrichment of Prevotella sp.
Weixuan Tang, Yangyi Hao, Jiawei Zhang, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Shengli Li   +7 more
wiley   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Variations in trajectories of emotional and behavioural symptoms in children and young people with pre‐existing mental health and neurodevelopmental conditions before and during the COVID‐19 pandemic: A nested data linkage clinical cohort study

JCPP Advances, EarlyView.
Abstract Background Children and young people with pre‐existing mental health and neurodevelopmental conditions may have experienced heterogeneous mental health impacts during the COVID‐19 pandemic, but what facts may explain these variations are still unclear. We aimed to examine variations in the longitudinal trajectories of emotional and behavioural
Brian C. F. Ching, Alice Wickersham, Dominic Stringer, Sarjhana Ragunathan Brindha, Craig Colling, Ruby Morton, Valeria Parlatini, Johnny Downs, Emily Simonoff   +8 more
wiley   +1 more source

Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice. [PDF]

Genetics
Risemberg EL, Leist SR, Schäfer A, Kamat KD, Bell TA, Hock P, Jensen KL, Linnertz CL, Miller DR, Shaw GD, Pardo Manuel de Villena F, Baric RS, Ferris MT, Valdar W.   +13 more
europepmc   +1 more source